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  2. FCEN
  3. FCEN - Facultad de Ciencias Exactas y Naturales. UBA
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dc.provenanceFacultad de Ciencias Exactas y Naturales de la UBA-
dc.contributor<div class="autor_fcen" id="559">Ballestero, J.</div>-
dc.contributorde San Martín, J.Z.-
dc.contributor<div class="autor_fcen" id="3956">Goutman, J.</div>-
dc.contributorElgoyhen, A.B.-
dc.contributorFuchs, P.A.-
dc.contributor<div class="autor_fcen" id="4549">Katz, E.</div>-
dc.creator<div class="autor_fcen" id="559">Ballestero, J.</div>-
dc.creatorde San Martín, J.Z.-
dc.creator<div class="autor_fcen" id="3956">Goutman, J.</div>-
dc.creatorElgoyhen, A.B.-
dc.creatorFuchs, P.A.-
dc.creator<div class="autor_fcen" id="4549">Katz, E.</div>-
dc.date.accessioned2018-05-04T21:58:25Z-
dc.date.accessioned2018-05-28T15:48:30Z-
dc.date.available2018-05-04T21:58:25Z-
dc.date.available2018-05-28T15:48:30Z-
dc.date.issued2011-
dc.identifier.urihttp://10.0.0.11:8080/jspui/handle/bnmm/68496-
dc.descriptionIn the mammalian inner ear, the gain control of auditory inputs is exerted by medial olivocochlear (MOC) neurons that innervate cochlear outer hair cells (OHCs). OHCs mechanically amplify the incoming sound waves by virtue of their electromotile properties while the MOC system reduces the gain of auditory inputs by inhibiting OHC function. How this process is orchestrated at the synaptic level remains unknown. In the present study, MOC firing was evoked by electrical stimulation in an isolated mouse cochlear preparation, while OHCs postsynaptic responses were monitored by whole-cell recordings. These recordings confirmed that electrically evoked IPSCs (eIPSCs) are mediated solely by α9β10 nAChRs functionally coupled to calcium-activated SK2 channels. Synaptic release occurred with low probability when MOC-OHC synapses were stimulated at 1 Hz. However, as the stimulation frequency was raised, the reliability of release increased due to presynaptic facilitation. In addition, the relatively slow decay of eIPSCs gave rise to temporal summation at stimulation frequencies >10 Hz. The combined effect of facilitation and summation resulted in a frequency-dependent increase in the average amplitude of inhibitory currents in OHCs. Thus, we have demonstrated that short-term plasticity is responsible for shaping MOC inhibition and, therefore, encodes the transfer function from efferent firing frequency to the gain of the cochlear amplifier. © 2011 the authors.-
dc.descriptionFil:Ballestero, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.-
dc.descriptionFil:Goutman, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.-
dc.descriptionFil:Katz, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.-
dc.formatapplication/pdf-
dc.languageeng-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by/2.5/ar-
dc.sourceJ. Neurosci. 2011;31(41):14763-14774-
dc.source.urihttp://digital.bl.fcen.uba.ar/Download/paper/paper_02706474_v31_n41_p14763_Ballestero.pdf-
dc.subjectalpha9alpha10 nicotinic acetylcholine receptor-
dc.subjectcalcium activated potassium channel-
dc.subjectnicotinic receptor-
dc.subjectSK2 channel-
dc.subjectunclassified drug-
dc.subjectanimal tissue-
dc.subjectarticle-
dc.subjectbrain nerve cell-
dc.subjectcochlea-
dc.subjectcontrolled study-
dc.subjectelectrostimulation-
dc.subjectfacilitation-
dc.subjectfemale-
dc.subjecthair cell-
dc.subjectinhibitory postsynaptic potential-
dc.subjectmale-
dc.subjectmedial olivocochlear neuron-
dc.subjectmouse-
dc.subjectnerve cell plasticity-
dc.subjectneurotransmitter release-
dc.subjectnewborn-
dc.subjectnonhuman-
dc.subjectpresynaptic facilitation-
dc.subjectpriority journal-
dc.subjectsynaptic transmission-
dc.subjecttemporal summation-
dc.subjectAcoustic Stimulation-
dc.subjectAnimals-
dc.subjectAnimals, Newborn-
dc.subjectBiophysics-
dc.subjectChelating Agents-
dc.subjectCochlea-
dc.subjectCochlear Nerve-
dc.subjectEgtazic Acid-
dc.subjectElectric Stimulation-
dc.subjectFemale-
dc.subjectGlycine Agents-
dc.subjectHair Cells, Auditory-
dc.subjectIndoles-
dc.subjectInhibitory Postsynaptic Potentials-
dc.subjectMale-
dc.subjectMice-
dc.subjectMice, Inbred BALB C-
dc.subjectNeural Inhibition-
dc.subjectPatch-Clamp Techniques-
dc.subjectPeptides-
dc.subjectSerotonin Antagonists-
dc.subjectSodium Channel Blockers-
dc.subjectStrychnine-
dc.subjectSynapses-
dc.subjectTemperature-
dc.subjectTetrodotoxin-
dc.subjectTime Factors-
dc.titleShort-term synaptic plasticity regulates the level of olivocochlear inhibition to auditory hair cells-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:ar-repo/semantics/artículo-
dc.typeinfo:eu-repo/semantics/publishedVersion-
Aparece en las colecciones: FCEN - Facultad de Ciencias Exactas y Naturales. UBA

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