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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | Comisión de Investigaciones Científicas | - |
| dc.contributor | Cortizo, Ana María | - |
| dc.contributor | Ruderman, Graciela | - |
| dc.contributor | Correa, Gimena | - |
| dc.contributor | Mogilner, Inés G. | - |
| dc.contributor | Tolosa, Eduardo J. | - |
| dc.creator | Cortizo, Ana María | - |
| dc.creator | Ruderman, Graciela | - |
| dc.creator | Correa, Gimena | - |
| dc.creator | Mogilner, Inés G. | - |
| dc.creator | Tolosa, Eduardo J. | - |
| dc.date | 2012 | - |
| dc.date.accessioned | 2019-04-29T16:11:56Z | - |
| dc.date.available | 2019-04-29T16:11:56Z | - |
| dc.date.issued | 2012 | - |
| dc.identifier | http://digital.cic.gba.gob.ar/handle/11746/4454 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/311484 | - |
| dc.description | We have developed a biomimetic scaffold for tissue engineering using bovine collagen with different topographic characteristics, using matrices with random or parallel-arranged collagen fibres. Scaffolds were characterized by SEM, water contact angle and mechanical test. Biocompatiblitiy studies were performed with MC3T3E1 pre-osteoblasts, and adhesion, proliferation, differentiation and mineralization were assessed. Random film showed a smooth surface, while the ordered membrane revealed a grooved structure with channels separated 265 m from each other. Water contact angle was dependent on the direction of observation and the mechanical evaluation showed a lower resistance to traction and a greater ductility for the ordered membrane. Adhesion, proliferation, alkaline phosphatase activity and mineralization were significantly improved when cells were grown on the ordered-collagen matrix. There was no significant increase in pro-inflammatory cytokine release from cells grown on both random and ordered-collagen films. This material could be useful for bone tissue regeneration. | - |
| dc.format | application/pdf | - |
| dc.format | 8 p. | - |
| dc.language | eng | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | Attribution 4.0 International (BY 4.0) | - |
| dc.source | reponame:CIC Digital (CICBA) | - |
| dc.source | instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires | - |
| dc.source | instacron:CICBA | - |
| dc.source.uri | http://digital.cic.gba.gob.ar/handle/11746/4454 | - |
| dc.subject | Ciencias Químicas | - |
| dc.title | Effect of Surface Topography of Collagen Scaffolds on Cytotoxicity and Osteoblast Differentiation | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/submittedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | Comisión de Investigaciones Científicas de la Prov. de Buenos Aires | |
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