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dc.creatorMatarin, Mar-
dc.creatorSalih, Dervis A.-
dc.creatorYasvoina, Marina-
dc.creatorCummings, Damian M.-
dc.creatorGuelfi, Sebastian-
dc.creatorLiu, Wenfei-
dc.creatorNahabooSolim, Muzammil A.-
dc.creatorMoens, Thomas G.-
dc.creatorPaublete, Rocio Moreno-
dc.creatorAli, Shabinah S.-
dc.creatorPerona, Marina-
dc.creatorDesai, Roshni-
dc.creatorSmith, Kenneth J.-
dc.creatorLatcham, Judy-
dc.creatorFulleylove, Michael-
dc.creatorRichardson, Jill C.-
dc.creatorHardy, John-
dc.creatorEdwards, Frances A.-
dc.date2018-07-11T15:35:44Z-
dc.date2018-07-11T15:35:44Z-
dc.date2015-02-
dc.date2018-07-05T13:15:20Z-
dc.date.accessioned2019-04-29T15:57:10Z-
dc.date.available2019-04-29T15:57:10Z-
dc.identifierMatarin, Mar; Salih, Dervis A.; Yasvoina, Marina; Cummings, Damian M.; Guelfi, Sebastian; et al.; A Genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology; Elsevier; Cell Reports; 10; 4; 2-2015; 633-645-
dc.identifier2211-1247-
dc.identifierhttp://hdl.handle.net/11336/51730-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/306086-
dc.descriptionWe provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene). Microarray data were validated by qPCR and by comparison to human studies, including genome-wide association study (GWAS) hits. Immune gene expression correlated tightly with plaques whereas synaptic genes correlated negatively with neurofibrillary tangles. Network analysis of immune gene modules revealed six hub genes in hippocampus of amyloid mice, four in common with cortex. The hippocampal network in TAU mice was similar except that Trem2 had hub status only in amyloid mice. The cortical network of TAU mice was entirely different with more hub genes and few in common with the other networks, suggesting reasons for specificity of cortical dysfunction in FTDP17. This Resource opens up many areas for investigation. All data are available and searchable at http://www.mouseac.org.-
dc.descriptionFil: Matarin, Mar. Queen Square. Institute of Neurology. Department of Clinical and Experimental Epilepsy; Reino Unido. Physiology and Pharmacology. Department of Neuroscience; Reino Unido-
dc.descriptionFil: Salih, Dervis A.. Physiology and Pharmacology. Department of Neuroscience; Reino Unido-
dc.descriptionFil: Yasvoina, Marina. Physiology and Pharmacology. Department of Neuroscience; Reino Unido-
dc.descriptionFil: Cummings, Damian M.. Physiology and Pharmacology. Department of Neuroscience; Reino Unido-
dc.descriptionFil: Guelfi, Sebastian. Institute of Neurology. Reta Lila Research Laboratories and Department of Molecular Neuroscience; Reino Unido-
dc.descriptionFil: Liu, Wenfei. Physiology and Pharmacology. Department of Neuroscience; Reino Unido-
dc.descriptionFil: NahabooSolim, Muzammil A.. Physiology and Pharmacology. Department of Neuroscience; Reino Unido. Queen Square. UCL Institute of Neurology. Department of Neuroinflammation; Reino Unido-
dc.descriptionFil: Moens, Thomas G.. Physiology and Pharmacology. Department of Neuroscience; Reino Unido-
dc.descriptionFil: Paublete, Rocio Moreno. Physiology and Pharmacology. Department of Neuroscience; Reino Unido-
dc.descriptionFil: Ali, Shabinah S.. Physiology and Pharmacology. Department of Neuroscience; Reino Unido-
dc.descriptionFil: Perona, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Queen Square. Institute of Neurology. Department of Clinical and Experimental Epilepsy; Reino Unido-
dc.descriptionFil: Desai, Roshni. Queen Square. UCL Institute of Neurology. Department of Neuroinflammation; Reino Unido-
dc.descriptionFil: Smith, Kenneth J.. Queen Square. UCL Institute of Neurology. Department of Neuroinflammation; Reino Unido-
dc.descriptionFil: Latcham, Judy. GlaxoSmithKline R&D. Department of Laboratory Animal Science; Reino Unido-
dc.descriptionFil: Fulleylove, Michael. GlaxoSmithKline R&D. Department of Laboratory Animal Science; Reino Unido-
dc.descriptionFil: Richardson, Jill C.. GlaxoSmithKline R&D. Neurosciences Therapeutic Area; Reino Unido-
dc.descriptionFil: Hardy, John. Queen Square. Institute of Neurology. Department of Clinical and Experimental Epilepsy; Reino Unido-
dc.descriptionFil: Edwards, Frances A.. Queen Square. Institute of Neurology. Department of Clinical and Experimental Epilepsy; Reino Unido-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherElsevier-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.celrep.2014.12.041-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124714010948-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectGENE EXPRESSION-
dc.subjectAMILOYD-
dc.subjectTAU-
dc.subjectPATHOLOGY-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleA Genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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