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dc.creatorRamos Elizagaray, Sabrina I.-
dc.creatorSoria, Elio Andres-
dc.date2017-01-17T21:55:38Z-
dc.date2017-01-17T21:55:38Z-
dc.date2014-07-
dc.date2017-01-13T19:40:11Z-
dc.date.accessioned2019-04-29T15:55:57Z-
dc.date.available2019-04-29T15:55:57Z-
dc.identifierRamos Elizagaray, Sabrina I.; Soria, Elio Andres; Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches; Bentham Science Publishers; Recent Patents on Inflammation and Allergy Drug Discovery; 8; 2; 7-2014; 92-103-
dc.identifier1872-213X-
dc.identifierhttp://hdl.handle.net/11336/11539-
dc.identifier2212-2710-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/305642-
dc.descriptionArsenic (As) contaminates drinking water worldwide, and As exposure, hypersensitivity and deficiency are involved in the immunopathogenesis of various health problems. Its chemoprevention thus has a high health impact. Given its oxidative potential, antioxidant compounds are good candidates to counteract arsenic's deleterious effects on humans. Phytochemicals (e.g., phenolics, carotenoids, etc.) act through free radical chelation activity and regulation of cellular targets. Consequently, they are appropriate for developing anti-As strategies derived from plants, and Argentinean flora is rich in useful species. Several molecular pathways involved in immune regulation are at the same time targets of exogenous agents, and oxidative stress itself is a modulating phenomenon of immunity. Since xenohormesis has been described as the organic enhancement of resistance to stress conditions (e.g., oxidation, pollution, etc.) by consuming xenobiotics, immunoxenohormesis implies also defense improvement. This review focuses on recent patents on the development of vegetable redox-related immunomodulating agents, which might be applied in As-induced dysfunctions, with their scientific basis being reviewed.-
dc.descriptionFil: Ramos Elizagaray, Sabrina I.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; Argentina. Consejo Interuniversitario Nacional; Argentina-
dc.descriptionFil: Soria, Elio Andres. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherBentham Science Publishers-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://benthamscience.com/journals/recent-patents-on-inflammation-and-allergy-drug-discovery/volume/8/issue/2/page/92/-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.2174/1872213X08666140619104944-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectAntioxidant-
dc.subjectArsenicosis-
dc.subjectChemoprevention-
dc.subjectPhytomedicine-
dc.subjectImmunomodulation-
dc.subjectPolyphenol-
dc.subjectFarmacología y Farmacia-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleArsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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