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dc.creatorVarani, Andrés P.-
dc.creatorAso, Ester-
dc.creatorMaldonado, Rafael-
dc.creatorBalerio, Graciela Noemí-
dc.date2017-03-06T20:17:38Z-
dc.date2017-03-06T20:17:38Z-
dc.date2014-09-
dc.date2017-03-06T15:25:31Z-
dc.date.accessioned2019-04-29T15:54:15Z-
dc.date.available2019-04-29T15:54:15Z-
dc.date.issued2014-09-
dc.identifierVarani, Andrés P.; Aso, Ester; Maldonado, Rafael; Balerio, Graciela Noemí; Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine; Elsevier Science; European Journal Of Pharmacology; 738; 9-2014; 200-205-
dc.identifier0014-2999-
dc.identifierhttp://hdl.handle.net/11336/13587-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/305079-
dc.descriptionThe aim of the present study was to evaluate the possible involvement of GABAB receptors in nicotine-induced hypolocomotion and antinociceptive effects in mice. Animals were exposed to nicotine only once. Acute nicotine hydrogen tartrate salt (3 mg/kg; subcutaneous, s.c.) administration induced hypolocomotion and antinociceptive responses in the tail-immersion and the hot-plate tests. The effects of pretreatment with either the GABAB receptor agonist baclofen (1, 2 and 3 mg/kg; intraperitoneal, i.p.) or GABAB receptor antagonist 2-hydroxysaclofen (0.25, 0.5 and 1 mg/kg; i.p.) were evaluated on these behavioral nicotine responses. The GABAB receptor agonist, baclofen (3 mg/kg, i.p.) abolished nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, but did not modify nicotine-induced hypolocomotion. In addition, the GABAB receptor antagonist, 2-hydroxysaclofen (1 mg/kg, i.p.) increased nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, and abolished nicotine-induced hypolocomotion. The present results shed light that the GABAB receptor has an important role in mediating specific acute nicotine responses such as hypolocomotion and antinociception in mice.-
dc.descriptionFil: Varani, Andrés P.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina-
dc.descriptionFil: Aso, Ester. Universitat Pompeu Fabra; España-
dc.descriptionFil: Maldonado, Rafael. Universitat Pompeu Fabra; España-
dc.descriptionFil: Balerio, Graciela Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherElsevier Science-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0014299914004014-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http:/dx.doi.org/10.1016/j.ejphar.2014.05.039-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectnicotin-
dc.subjectbaclofen-
dc.subject2-hydroxysaclofen-
dc.subjectGABA B receptors-
dc.subjectnociception-
dc.subjectlocomotion-
dc.subjectDrogadicción-
dc.subjectCiencias de la Salud-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleBaclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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