Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Fermino, Marise L. | - |
| dc.creator | Dias, Fabrício C. | - |
| dc.creator | Lopes, Carla D. | - |
| dc.creator | Souza, Maria A. | - |
| dc.creator | Cruz, Ângela K. | - |
| dc.creator | Liu, Fu Tong | - |
| dc.creator | Chammas, Roger | - |
| dc.creator | Roque Barreira, Maria C. | - |
| dc.creator | Rabinovich, Gabriel Adrian | - |
| dc.creator | Bernardes, Emerson S. | - |
| dc.date | 2015-10-06T18:15:10Z | - |
| dc.date | 2015-10-06T18:15:10Z | - |
| dc.date | 2013-05-17 | - |
| dc.date | 2016-03-30 10:35:44.97925-03 | - |
| dc.date.accessioned | 2019-04-29T15:52:51Z | - |
| dc.date.available | 2019-04-29T15:52:51Z | - |
| dc.date.issued | 2013-05-17 | - |
| dc.identifier | Marise L. Fermino; Fabrício C. Dias; Carla D. Lopes; Maria A. Souza; Ângela K. Cruz; et al.; Galectin-3 negatively regulates the frequency and function of CD4(+) CD25(+) Foxp3(+) regulatory T cells and influences the course of Leishmania major infection; Wiley Vch Verlag; European Journal Of Immunology; 43; 7; 17-5-2013; 1806-1817 | - |
| dc.identifier | 0014-2980 | - |
| dc.identifier | http://hdl.handle.net/11336/2356 | - |
| dc.identifier | 1521-4141 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/304475 | - |
| dc.description | Galectin-3, an endogenous glycan-binding protein, plays essential roles during microbial infection by modulating innate and adaptive immunity. However, the role of galectin-3 within the CD4+CD25+Foxp3+ T regulatory (TREG) cell compartment has not yet been explored. Here, we found, in a model of Leishmania major infection, that galectin-3 deficiency increases the frequency of peripheral TREG cells both in draining lymph nodes (LNs) and sites of infection. These observations correlated with an increased severity of the disease, as shown by increased footpad swelling and parasite burden. Galectin-3-deficient (Lgals3−/−) TREG cells displayed higher CD103 expression, showed greater suppressive capacity, and synthesized higher amounts of IL-10 compared with their wild-type (WT) counterpart. Furthermore, both TREG cells and T effector (TEFF) cells from Lgals3−/− mice showed higher expression of Notch1 and the Notch target gene Hes-1. Interestingly, Notch signaling components were also altered in both TREG and TEFF cells from uninfected Lgals3−/− mice. Thus, endogenous galectin-3 regulates the frequency and function of CD4+CD25+Foxp3+ TREG cells and alters the course of L. major infection. | - |
| dc.description | Fil: Fermino, Marise L.. Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biologia Celular e Molecular; Brasil; | - |
| dc.description | Fil: Dias, Fabrício C.. Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biologia Celular e Molecular; Brasil; | - |
| dc.description | Fil: Lopes, Carla D.. Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biologia Celular e Molecular; Brasil; | - |
| dc.description | Fil: Souza, Maria A.. Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biologia Celular e Molecular; Brasil; Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Departamento de Imunologia; Brasil; | - |
| dc.description | Fil: Cruz, Ângela K.. Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biologia Celular e Molecular; Brasil; | - |
| dc.description | Fil: Liu, Fu Tong. University of California Davis. School of Medicine. Department of Dermatology; Estados Unidos de Amèrica; | - |
| dc.description | Fil: Chammas, Roger. Universidade de São Paulo. Faculdade de Medicina. Departamento de Radiologia e Oncologia; Brasil; Cancer Institute of the State of Sao Paulo. Center for Translational Research in Oncology; Brasil; | - |
| dc.description | Fil: Roque Barreira, Maria C.. Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biologia Celular e Molecular; Brasil; | - |
| dc.description | Fil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina; | - |
| dc.description | Fil: Bernardes, Emerson S.. Universidade de São Paulo. Faculdade de Medicina. Departamento de Radiologia e Oncologia; Brasil; Cancer Institute of the State of Sao Paulo. Center for Translational Research in Oncology; Brasil; | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley VCH Verlag | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/eji.201343381 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/eji.201343381/abstract;jsessionid=67113EC5897BBBED63DAF7E40BDBBE33.f03t04 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | PARASITE | - |
| dc.subject | LEISHMANIASIS | - |
| dc.subject | GALECTIN-3 | - |
| dc.subject | T REGULATORY CELLS | - |
| dc.subject | IL-10 | - |
| dc.subject | Leishmania major | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Galectin-3 negatively regulates the frequency and function of CD4(+) CD25(+) Foxp3(+) regulatory T cells and influences the course of Leishmania major infection | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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