Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Murta, Verónica | - |
| dc.creator | Schilrreff, Priscila | - |
| dc.creator | Rosciszewski, Gerardo Ariel | - |
| dc.creator | Morrilla, Maria Jose | - |
| dc.creator | Ramos, Alberto Javier | - |
| dc.date | 2018-04-09T18:52:33Z | - |
| dc.date | 2018-04-09T18:52:33Z | - |
| dc.date | 2018-01 | - |
| dc.date | 2018-04-09T15:19:15Z | - |
| dc.date.accessioned | 2019-04-29T15:51:12Z | - |
| dc.date.available | 2019-04-29T15:51:12Z | - |
| dc.date.issued | 2018-01 | - |
| dc.identifier | Murta, Verónica; Schilrreff, Priscila; Rosciszewski, Gerardo Ariel; Morrilla, Maria Jose; Ramos, Alberto Javier; G5G2.5 core-shell tecto-dendrimer specifically targets reactive glia in brain ischemia; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 1-2018 | - |
| dc.identifier | 0022-3042 | - |
| dc.identifier | http://hdl.handle.net/11336/41380 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303753 | - |
| dc.description | Secondary neuronal death is a serious stroke complication. That process is facilitated by the conversion of glial cells to the reactive proinflammatory phenotype that induces neurodegeneration. Therefore, regulation of glial activation is a compelling strategy to reduce brain damage after stroke. However, drugs have difficulties to access the central nervous system (CNS), and to specifically target glial cells. In the present work we explored the use core-shell polyamidoamine tecto-dendrimer (G5G2.5 PAMAM) and studied its ability to target distinct populations of stroke-activated glial cells. We found that G5G2.5 tecto-dendrimer is actively engulfed by primary glial cells in a time- and dose-dependent manner showing high cellular selectivity and lysosomal localization. In addition, oxygen-glucose deprivation or lipopolysaccharides (LPS) exposure in vitro and brain ischemia in vivo increase glial G5G2.5 uptake; not being incorporated by neurons or other cell types. We conclude that G5G2.5 tecto-dendrimer is a highly suitable carrier for targeted drug delivery to reactive glial cells in vitro and in vivo after brain ischemia. | - |
| dc.description | Fil: Murta, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.description | Fil: Schilrreff, Priscila. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina | - |
| dc.description | Fil: Rosciszewski, Gerardo Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.description | Fil: Morrilla, Maria Jose. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina | - |
| dc.description | Fil: Ramos, Alberto Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley Blackwell Publishing, Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1111/jnc.14286 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.14286 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Astrocyte | - |
| dc.subject | Neuroinflammation | - |
| dc.subject | Nanoparticle | - |
| dc.subject | Stroke | - |
| dc.subject | Nano-materiales | - |
| dc.subject | Nanotecnología | - |
| dc.subject | INGENIERÍAS Y TECNOLOGÍAS | - |
| dc.title | G5G2.5 core-shell tecto-dendrimer specifically targets reactive glia in brain ischemia | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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