Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Abatángelo, Virginia | - |
| dc.creator | Peressutti Bacci, Natalia | - |
| dc.creator | Boncompain, Carina Andrea | - |
| dc.creator | Amadio, Ariel Fernando | - |
| dc.creator | Carrasco, Soledad Telma | - |
| dc.creator | Suárez, Cristian Alejandro | - |
| dc.creator | Morbidoni, Héctor Ricardo | - |
| dc.date | 2019-01-22T15:09:16Z | - |
| dc.date | 2019-01-22T15:09:16Z | - |
| dc.date | 2017-07 | - |
| dc.date | 2019-01-07T13:58:06Z | - |
| dc.date.accessioned | 2019-04-29T15:51:04Z | - |
| dc.date.available | 2019-04-29T15:51:04Z | - |
| dc.date.issued | 2017-07 | - |
| dc.identifier | Abatángelo, Virginia; Peressutti Bacci, Natalia; Boncompain, Carina Andrea; Amadio, Ariel Fernando; Carrasco, Soledad Telma; et al.; Broad-range lytic bacteriophages that kill Staphylococcus aureus local field strains; Public Library of Science; Plos One; 12; 10; 7-2017; e0187387 | - |
| dc.identifier | http://hdl.handle.net/11336/68367 | - |
| dc.identifier | 1932-6203 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303684 | - |
| dc.description | Staphylococcus aureus is a very successful opportunistic pathogen capable of causing a variety of diseases ranging from mild skin infections to life-threatening sepsis, meningitis and pneumonia. Its ability to display numerous virulence mechanisms matches its skill to display resistance to several antibiotics, including β-lactams, underscoring the fact that new anti-S. aureus drugs are urgently required. In this scenario, the utilization of lytic bacteriophages that kill bacteria in a genus -or even species- specific way, has become an attractive field of study. In this report, we describe the isolation, characterization and sequencing of phages capable of killing S. aureus including methicillin resistant (MRSA) and multi-drug resistant S. aureus local strains from environmental, animal and human origin. Genome sequencing and bio-informatics analysis showed the absence of genes encoding virulence factors, toxins or antibiotic resistance determinants. Of note, there was a high similarity between our set of phages to others described in the literature such as phage K. Considering that reported phages were obtained in different continents, it seems plausible that there is a commonality of genetic features that are needed for optimum, broad host range anti-staphylococcal activity of these related phages. Importantly, the high activity and broad host range of one of our phages underscores its promising value to control the presence of S. aureus in fomites, industry and hospital environments and eventually on animal and human skin. The development of a cocktail of the reported lytic phages active against S. aureus–currently under way- is thus, a sensible strategy against this pathogen. | - |
| dc.description | Fil: Abatángelo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina | - |
| dc.description | Fil: Peressutti Bacci, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina | - |
| dc.description | Fil: Boncompain, Carina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina | - |
| dc.description | Fil: Amadio, Ariel Fernando. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina | - |
| dc.description | Fil: Carrasco, Soledad Telma. Universidad Nacional de Rosario; Argentina | - |
| dc.description | Fil: Suárez, Cristian Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina | - |
| dc.description | Fil: Morbidoni, Héctor Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Public Library of Science | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1371/journal.pone.0181671 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181671 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | BACTERIOPHAGES | - |
| dc.subject | BIOCONTROL | - |
| dc.subject | BIOINFORMATICS | - |
| dc.subject | STAPHYLOCOCCUS | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Broad-range lytic bacteriophages that kill Staphylococcus aureus local field strains | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.