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dc.creatorHuetteroth, Wolf-
dc.creatorPerisse, Emmanuel-
dc.creatorLin, Suewei-
dc.creatorKlappenbach, Martín-
dc.creatorBurke, Christopher-
dc.creatorWaddell, Scott-
dc.date2018-03-08T20:28:19Z-
dc.date2018-03-08T20:28:19Z-
dc.date2015-03-
dc.date2018-03-02T14:18:25Z-
dc.date.accessioned2019-04-29T15:49:37Z-
dc.date.available2019-04-29T15:49:37Z-
dc.date.issued2015-03-
dc.identifierHuetteroth, Wolf; Perisse, Emmanuel; Lin, Suewei; Klappenbach, Martín; Burke, Christopher; et al.; Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila; Cell Press; Current Biology; 25; 6; 3-2015; 751-758-
dc.identifier0960-9822-
dc.identifierhttp://hdl.handle.net/11336/38320-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303080-
dc.descriptionDopaminergic neurons provide reward learning signals in mammals and insects [1-4]. Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons are different to those for nutritious sugars [5]. Here, we tested whether the sweet taste and nutrient properties of sugar reinforcement further subdivide the fly reward system. We found that dopaminergic neurons expressing the OAMB octopamine receptor [6] specifically convey the short-term reinforcing effects of sweet taste [4]. These dopaminergic neurons project to the β′2 and γ4 regions of the mushroom body lobes. In contrast, nutrient-dependent long-term memory requires different dopaminergic neurons that project to the γ5b regions, and it can be artificially reinforced by those projecting to the β lobe and adjacent α1 region. Surprisingly, whereas artificial implantation and expression of short-term memory occur in satiated flies, formation and expression of artificial long-term memory require flies to be hungry. These studies suggest that short-term and long-term sugar memories have different physiological constraints. They also demonstrate further functional heterogeneity within the rewarding dopaminergic neuron population.-
dc.descriptionFil: Huetteroth, Wolf. University of Oxford; Reino Unido. University of Konstanz; Alemania-
dc.descriptionFil: Perisse, Emmanuel. University of Oxford; Reino Unido-
dc.descriptionFil: Lin, Suewei. University of Oxford; Reino Unido-
dc.descriptionFil: Klappenbach, Martín. University of Oxford; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina-
dc.descriptionFil: Burke, Christopher. University of Oxford; Reino Unido-
dc.descriptionFil: Waddell, Scott. University of Oxford; Reino Unido-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherCell Press-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cub.2015.01.036-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960982215000688-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectDopamine-
dc.subjectReward-
dc.subjectDrosophila-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleSweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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