Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Matarrese, Paola | - |
| dc.creator | Tinari, Antonella | - |
| dc.creator | Mormone, Elisabetta | - |
| dc.creator | Bianco, German Ariel | - |
| dc.creator | Toscano, Marta Alicia | - |
| dc.creator | Ascione, Barbara | - |
| dc.creator | Rabinovich, Gabriel Adrián | - |
| dc.creator | Malorni, Walter | - |
| dc.date | 2017-12-22T05:26:53Z | - |
| dc.date | 2017-12-22T05:26:53Z | - |
| dc.date | 2005-11-19 | - |
| dc.date | 2017-12-19T18:36:40Z | - |
| dc.date.accessioned | 2019-04-29T15:49:31Z | - |
| dc.date.available | 2019-04-29T15:49:31Z | - |
| dc.date.issued | 2005-11-19 | - |
| dc.identifier | Malorni, Walter; Rabinovich, Gabriel Adrián; Ascione, Barbara; Toscano, Marta Alicia; Bianco, German Ariel; Mormone, Elisabetta; et al.; Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission.; American Society for Biochemistry and Molecular Biology; Journal of Biological Chemistry (online); 280; 8; 19-11-2005; 6969-6985 | - |
| dc.identifier | 0021-9258 | - |
| dc.identifier | http://hdl.handle.net/11336/31343 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303037 | - |
| dc.description | Galectins have emerged as a novel family of immunoregulatory proteins implicated in T cell homeostasis. Recent studies showed that galectin-1 (Gal-1) plays a key role in tumor-immune escape by killing antitumor effector T cells. Here we found that Gal-1 sensitizes human resting T cells to Fas (CD95)/caspase-8-mediated cell death. Furthermore, this protein triggers an apoptotic program involving an increase of mitochondrial membrane potential and participation of the ceramide pathway. In addition, Gal-1 induces mitochondrial coalescence, budding, and fission accompanied by an increase and/or redistribution of fission-associated molecules h-Fis and DRP-1. Importantly, these changes are detected in both resting and activated human T cells, suggesting that Gal-1-induced cell death might become an excellent model to analyze the morphogenetic changes of mitochondria during the execution of cell death. This is the first association among Gal-1, Fas/Fas ligand-mediated cell death, and the mitochondrial pathway, providing a rational basis for the immunoregulatory properties of Gal-1 in experimental models of chronic inflammation and cancer. | - |
| dc.description | Fil: Matarrese, Paola. Istituto Superiore di Sanità; Italia | - |
| dc.description | Fil: Tinari, Antonella. Istituto Superiore di Sanità; Italia | - |
| dc.description | Fil: Mormone, Elisabetta. Istituto Superiore di Sanità; Italia | - |
| dc.description | Fil: Bianco, German Ariel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina | - |
| dc.description | Fil: Toscano, Marta Alicia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Ascione, Barbara. Istituto Superiore di Sanità; Italia | - |
| dc.description | Fil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Malorni, Walter. Istituto Superiore di Sanità; Italia | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Society for Biochemistry and Molecular Biology | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.jbc.org/content/280/8/6969.long | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1074/jbc.M409752200 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/15556941 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | GALECTIN-1 | - |
| dc.subject | CANCER | - |
| dc.subject | APOPTOSIS | - |
| dc.subject | MITOCHONDRIA | - |
| dc.subject | T-LYMPHOCYTES | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.subject | Patología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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