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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Buchet, Delphine | - |
| dc.creator | Garcia, Corina Ileana | - |
| dc.creator | Deboux, Cyrille | - |
| dc.creator | Nait Oumesmar, Brahim | - |
| dc.creator | Baron Van Evercooren, Anne | - |
| dc.date | 2017-02-13T19:38:33Z | - |
| dc.date | 2017-02-13T19:38:33Z | - |
| dc.date | 2011-04 | - |
| dc.date | 2017-02-09T18:23:19Z | - |
| dc.date.accessioned | 2019-04-29T15:49:23Z | - |
| dc.date.available | 2019-04-29T15:49:23Z | - |
| dc.date.issued | 2011-04 | - |
| dc.identifier | Buchet, Delphine; Garcia, Corina Ileana; Deboux, Cyrille; Nait Oumesmar, Brahim; Baron Van Evercooren, Anne; Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord; Oxford University Press; Brain; 134; 4; 4-2011; 1168-1183 | - |
| dc.identifier | 0006-8950 | - |
| dc.identifier | http://hdl.handle.net/11336/12921 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302980 | - |
| dc.description | Improving oligodendroglial differentiation from human foetal neural progenitor cells remains a primordial issue to accomplish successful cell-based therapies in myelin diseases. Here, we combined in situ, in vitro and in vivo approaches to assess the oligodendrogenic potential of different human foetal forebrain regions during the first trimester of gestation. We show for the first time that the initial wave of oligodendrocyte progenitor emergence in the ventral telencephalon onsets as early as 7.5 weeks into gestation. Interestingly, in vitro, isolation of ganglionic eminences yielded oligodendrocyte progenitor-enriched cultures, as compared with cortex and thalamus. Most importantly, single injection of human neural progenitors into rodent models of focal gliotoxic demyelination revealed the great capacity of these cells to survive, extensively migrate and successfully remyelinate the spinal cord, irrespective of their origin. Thus, our study brings novel insights into the biology of early human foetal neural progenitor cells and offers new support for the development of cellular therapeutics for myelin disorders. | - |
| dc.description | Fil: Buchet, Delphine. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia | - |
| dc.description | Fil: Garcia, Corina Ileana. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina | - |
| dc.description | Fil: Deboux, Cyrille. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia | - |
| dc.description | Fil: Nait Oumesmar, Brahim. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia | - |
| dc.description | Fil: Baron Van Evercooren, Anne. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre National de la Recherche Scientifique; Francia | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Oxford University Press | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awr030 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1093/brain/awr030 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | HUMAN NEURAL PROGENITOR CELLS | - |
| dc.subject | OLIGODENDROCYTE | - |
| dc.subject | MIGRATION | - |
| dc.subject | OLIGODENDROGENESIS | - |
| dc.subject | REMYELINATION | - |
| dc.subject | Neurociencias | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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