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dc.creatorMuller, Mariel-
dc.creatorHess, Leonardo-
dc.creatorTardivo, Agustina-
dc.creatorLajmanovich, Rafael Carlos-
dc.creatorAttademo, Andres Maximiliano-
dc.creatorPoletta, Gisela Laura-
dc.creatorSimoniello, Maria Fernanda-
dc.creatorYodice, Agustina-
dc.creatorLavarello, Simona-
dc.creatorChialvo, Dante Renato-
dc.creatorScremin, Oscar Umberto-
dc.date2017-12-13T16:26:50Z-
dc.date2017-12-13T16:26:50Z-
dc.date2014-09-
dc.date2017-12-11T15:06:14Z-
dc.date.accessioned2019-04-29T15:49:14Z-
dc.date.available2019-04-29T15:49:14Z-
dc.date.issued2014-09-
dc.identifierMuller, Mariel; Hess, Leonardo; Tardivo, Agustina; Lajmanovich, Rafael Carlos; Attademo, Andres Maximiliano; et al.; Neurologic dysfunction and genotoxicity induced by low levels of chlorpyrifos; Elsevier; Neurotoxicology And Teratology.; 45; 9-2014; 22-30-
dc.identifier0892-0362-
dc.identifierhttp://hdl.handle.net/11336/30417-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302912-
dc.descriptionChlorpyrifos (CPF) is an organophosphorus cholinesterase inhibitor widely used as an insecticide. Neuro and genotoxicity of this agent were evaluated following daily subcutaneous injections at 0.1, 1 and 10 mg/kg or its vehicle to laboratory rats during one week, at the end of which somatosensory evoked potentials (SEP) and power spectrum of the electroencephalogram (EEGp) were recorded under urethane anesthesia. In another group of conscious animals, auditory startle reflex (ASR) was evaluated followed, after euthanasia, with measurements of plasma B-esterases, and genotoxicity with the alkaline comet assay (ACA) at the same CPF doses. The results indicated a CPF dose related inhibition of B-esterases. Enhanced inhibition of the ASR by a subthreshold pre-pulse was observed at all doses and ACA showed a significant higher DNA damage than vehicle controls in animals exposed to 10 mg/kg CPF. A trend to higher frequencies of EEGp and an increase in amplitude of the first negative wave of the SEP were found at all doses. The first positive wave of the SEP decreased at the CPF dose of 10 mg/kg. In summary, a shift to higher EEG frequencies and alterations of somatosensory and auditory input to the central nervous system were sensitive manifestations of CPF toxicity, associated with depression of B-esterases. The changes in electrical activity of the cerebral cortex and DNA damage observed at doses that do not elicit overt toxicity may be useful in the detection of CPF exposure before clinical signs appear.-
dc.descriptionFil: Muller, Mariel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina-
dc.descriptionFil: Hess, Leonardo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina-
dc.descriptionFil: Tardivo, Agustina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina-
dc.descriptionFil: Lajmanovich, Rafael Carlos. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Attademo, Andres Maximiliano. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Poletta, Gisela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Toxicología y Bioquímica Legal; Argentina-
dc.descriptionFil: Simoniello, Maria Fernanda. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Toxicología y Bioquímica Legal; Argentina-
dc.descriptionFil: Yodice, Agustina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina-
dc.descriptionFil: Lavarello, Simona. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina-
dc.descriptionFil: Chialvo, Dante Renato. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Scremin, Oscar Umberto. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. University Of California At Los Angeles. School Of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
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dc.languageeng-
dc.publisherElsevier-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuro.2014.08.012-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0161813X1400151X-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectAcetylcholinesterase inhibitors-
dc.subjectComet assay-
dc.subjectAuditory startle-
dc.subjectEEG-
dc.subjectEvoked potentials-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleNeurologic dysfunction and genotoxicity induced by low levels of chlorpyrifos-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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