Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Ronchi, Virginia Paola | - |
| dc.creator | Giudici, Ana Marcela | - |
| dc.creator | Mendieta, Julieta Renee | - |
| dc.creator | Caballero, Veronica Jorgelina | - |
| dc.creator | Chisari, Andrea Nancy | - |
| dc.creator | Sanllorenti, Pedro M. | - |
| dc.creator | Conde, Ruben Danilo | - |
| dc.date | 2017-02-21T13:41:14Z | - |
| dc.date | 2017-02-21T13:41:14Z | - |
| dc.date | 2010-06 | - |
| dc.date | 2017-02-10T18:13:24Z | - |
| dc.date.accessioned | 2019-04-29T15:47:47Z | - |
| dc.date.available | 2019-04-29T15:47:47Z | - |
| dc.date.issued | 2010-06 | - |
| dc.identifier | Ronchi, Virginia Paola; Giudici, Ana Marcela; Mendieta, Julieta Renee; Caballero, Veronica Jorgelina; Chisari, Andrea Nancy; et al.; Oxidative stress in mouse liver caused by dietary amino acid deprivation : protective effect of methionine; Springer; Journal Of Physiology And Biochemistry; 66; 2; 6-2010; 93-103 | - |
| dc.identifier | 1138-7548 | - |
| dc.identifier | http://hdl.handle.net/11336/13227 | - |
| dc.identifier | 1877-8755 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302242 | - |
| dc.description | The aim of this work was to evaluate the effects of a diet depleted of amino acids (protein-free diet, or PFD), as well as the supplementation with methionine (PFD+Met), on the antioxidant status of the female mouse liver. With this purpose, cytosolic protein spots from two-dimensional non-equilibrium pH gel electrophoresis were identified by several procedures, such as mass spectrometry, Western blot, gel matching and enzymatic activity. PFD decreased the contents of catalase (CAT), peroxiredoxin I (Prx-I), and glutathione peroxidase (GPx) by 67%, 37% and 45%, respectively. Gene expression analyses showed that PFD caused a decrease in CAT (−20%) and GPx (−30%) mRNA levels but did not change that of Prx-I. It was also found that, when compared to a normal diet, PFD increased the liver contents of both reactive oxygen species (+50%) and oxidized protein (+88%) and decreased that of glutathione (−45%). Supplementation of PFD with Met prevented these latter effects to varying degrees, whereas CAT, Prx-I and GPx mRNA levels resulted unmodified. Present results suggest that dietary amino acid deprivation deranges the liver antioxidant defences, and this can be, in part, overcome by supplementation with Met. | - |
| dc.description | Fil: Ronchi, Virginia Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Biológicas; Argentina. Universidad Nacional de Mar del Plata; Argentina | - |
| dc.description | Fil: Giudici, Ana Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Biológicas; Argentina. Universidad Nacional de Mar del Plata; Argentina | - |
| dc.description | Fil: Mendieta, Julieta Renee. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Biológicas; Argentina. Universidad Nacional de Mar del Plata; Argentina | - |
| dc.description | Fil: Caballero, Veronica Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Biológicas; Argentina. Universidad Nacional de Mar del Plata; Argentina | - |
| dc.description | Fil: Chisari, Andrea Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Biológicas; Argentina. Universidad Nacional de Mar del Plata; Argentina | - |
| dc.description | Fil: Sanllorenti, Pedro M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Biológicas; Argentina. Universidad Nacional de Mar del Plata; Argentina | - |
| dc.description | Fil: Conde, Ruben Danilo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigaciones Biológicas; Argentina. Universidad Nacional de Mar del Plata; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Springer | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007/s13105-010-0014-x | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s13105-010-0014-x | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/13227 | - |
| dc.subject | mouse liver | - |
| dc.subject | protein-free diet | - |
| dc.subject | oxidative stress | - |
| dc.subject | methionine | - |
| dc.subject | antioxidant defences | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Oxidative stress in mouse liver caused by dietary amino acid deprivation : protective effect of methionine | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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