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dc.provenanceCONICET-
dc.creatorFabricius, Gabriel-
dc.creatorBergero, Paula Elena-
dc.creatorOrmazabal, Maximiliano Emanuel-
dc.creatorMaltz, Alberto-
dc.creatorHozbor, Daniela Flavia-
dc.date2016-04-22T17:09:52Z-
dc.date2016-04-22T17:09:52Z-
dc.date2012-06-
dc.date2016-05-06 15:52:43.262787-03-
dc.date.accessioned2019-04-29T15:47:26Z-
dc.date.available2019-04-29T15:47:26Z-
dc.date.issued2012-06-
dc.identifierFabricius, Gabriel; Bergero, Paula Elena; Ormazabal, Maximiliano Emanuel; Maltz, Alberto; Hozbor, Daniela Flavia; Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina; Cambridge University Press; Epidemiology and Infection; 141; 4; 6-2012; 718-734-
dc.identifier0950-2688-
dc.identifierhttp://hdl.handle.net/11336/5335-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302075-
dc.descriptionDue to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0-1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.-
dc.descriptionFil: Fabricius, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina-
dc.descriptionFil: Bergero, Paula Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina-
dc.descriptionFil: Ormazabal, Maximiliano Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Biotecnología y Biología Molecular; Argentina-
dc.descriptionFil: Maltz, Alberto. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Matematicas; Argentina-
dc.descriptionFil: Hozbor, Daniela Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Biotecnología y Biología Molecular; Argentina-
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dc.languageeng-
dc.publisherCambridge University Press-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://journals.cambridge.org/abstract_S0950268812001380-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1017/S0950268812001380-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1017/S0950268812001380-
dc.relationinfo:eu-repo/semantics/altIdentifier/pmid/22874088-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/5335-
dc.subjectEPIDEMIC-
dc.subjectMATHEMATICAL MODELLING-
dc.subjectPERTUSSIS-
dc.subjectTdap BOOSTER-
dc.subjectMatemática Aplicada-
dc.subjectMatemáticas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.subjectEnfermedades Infecciosas-
dc.subjectCiencias de la Salud-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.subjectBiofísica-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleModelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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