Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Bonetto, Julián Gerardo | - |
| dc.creator | Villaamil Lepori, Edda | - |
| dc.creator | Puntarulo, Susana Ángela | - |
| dc.date | 2018-12-06T17:28:26Z | - |
| dc.date | 2018-12-06T17:28:26Z | - |
| dc.date | 2017-10 | - |
| dc.date | 2018-10-23T19:44:34Z | - |
| dc.date.accessioned | 2019-04-29T15:46:56Z | - |
| dc.date.available | 2019-04-29T15:46:56Z | - |
| dc.date.issued | 2017-10 | - |
| dc.identifier | Bonetto, Julián Gerardo; Villaamil Lepori, Edda; Puntarulo, Susana Ángela; Oxidative balance in brain after exposure to arsenic in ex vivo and in vivo models; International Journal of advanced research; International Journal of Advanced Research; 5; 9; 10-2017; 41-51 | - |
| dc.identifier | 2320-5407 | - |
| dc.identifier | http://hdl.handle.net/11336/65980 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301851 | - |
| dc.description | The hypothesis of this work was that radical generation after exposure<br />to As may contribute to its toxic effects in the brain tissues. Oxidative<br />status of brain was studied, both using ex vivo and in vivo protocols of<br />exposure to the toxic. The generation rate of lipid radicals (LR●), and<br />ascorbyl radical (A●) content, were measured by Electron Paramagnetic<br />Resonance (EPR). In the ex vivo model control brain homogenates were<br />exposed to As, and a 2-fold increase was detected in the LR● generation<br />rate, with no changes in A● radical content. A significant decrease of<br />33% and 30% in the content of glutathione (GSH) was measured after<br />exposure to 3.3 and 4.0 pmol As/mg FW, respectively. In the in vivo<br />model, As was ip injected to rats and the rate of generation of LR● by<br />homogenates of brain tissue, was increased by 81 and 122%, as<br />compared to control animals after the injection of 3.0 and 5.8 mg<br />As/kg, respectively. Neither GSH, nor -tocopherol (-T) nor<br />ascorbate (AH-) content was affected in As-treated rats, as compared to<br />the values from control animals. The LR●/α-T content ratio was<br />significantly increased in As-treated animals as compared to control<br />brains. The A●/AH− content ratio was not affected by As exposure. The<br />content of total Fe showed non-significant differences between control<br />and rat brains after 24 h of As administration. The data presented here<br />showed new evidence on the generation of specific radical species by<br />As treatment employing EPR methodologies in both, ex vivo and in<br />vivo models. The data suggested the triggering of different pathways<br />leading to some reactive species generation may occur accordingly to<br />the via As reaches the brain, even when the same concentration of the<br />toxic was achieved by the tissues. | - |
| dc.description | Fil: Bonetto, Julián Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina | - |
| dc.description | Fil: Villaamil Lepori, Edda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina | - |
| dc.description | Fil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | International Journal of advanced research | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.21474/IJAR01/5505 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.journalijar.com/article/19981/oxidative-balance-in-brain-after-exposure-to-arsenic-in-ex-vivo-and-in-vivo-models./ | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Antioxidant | - |
| dc.subject | Arsenico | - |
| dc.subject | Brain | - |
| dc.subject | Epr detection | - |
| dc.subject | Otras Ciencias Químicas | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Oxidative balance in brain after exposure to arsenic in ex vivo and in vivo models | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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