Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Augner, Daniel | - |
| dc.creator | Krut, Oleg | - |
| dc.creator | Slavov, Nikolay | - |
| dc.creator | Gerbino, Darío César | - |
| dc.creator | Sahl, Hans Georg | - |
| dc.creator | Benting, Jürgen | - |
| dc.creator | Nising, Carl F. | - |
| dc.creator | Hillebrand, Stefan | - |
| dc.creator | Krönke, Martin | - |
| dc.creator | Schmalz, Hans-Günther | - |
| dc.date | 2016-04-28T15:44:37Z | - |
| dc.date | 2016-04-28T15:44:37Z | - |
| dc.date | 2013-08 | - |
| dc.date | 2016-05-06 15:52:43.262787-03 | - |
| dc.date.accessioned | 2019-04-29T15:46:56Z | - |
| dc.date.available | 2019-04-29T15:46:56Z | - |
| dc.date.issued | 2013-08 | - |
| dc.identifier | Augner, Daniel; Krut, Oleg; Slavov, Nikolay ; Gerbino, Darío César; Sahl, Hans Georg ; et al.; On the Antibiotic and Antifungal Activity of Pestalone, Pestalachloride A, and Structurally Related Compounds; American Chemical Society; Journal of Natural Products; 76; 8; 8-2013; 1519-1522 | - |
| dc.identifier | 0163-3864 | - |
| dc.identifier | http://hdl.handle.net/11336/5425 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301850 | - |
| dc.description | Pestalone (1) is a prominent marine natural product first isolated by M. Cueto et al. in 2001 from a cofermentation of a marine fungus with a marine bacterium. For more than 10 years, 1 had been considered as a promising new antibiotic compound, the reported MIC against methicillinresistant Staphylococcus aureus (MRSA) being 37 ng/mL. After overcoming the limited availability of 1 by total synthesis (N. Slavov et al., 2010) we performed new biological tests, which did not confirm the expected degree of antibiotic activity. The observed activity of pestalone against different MRSA strains was 3−10 μg/mL, as determined independently in two laboratories. A number of synthetic derivatives of 1 including pestalachloride A and other isoindolinones (formed from 1 by reaction with amines) did not exhibit higher activities as compared to 1 against MRSA and a series of plant pathogens. | - |
| dc.description | Fil: Augner, Daniel. Universitat Zu Koln; Alemania | - |
| dc.description | Fil: Krut, Oleg. Universitat Zu Koln; Alemania | - |
| dc.description | Fil: Slavov, Nikolay . Universitat Zu Koln; Alemania | - |
| dc.description | Fil: Gerbino, Darío César. Universidad Nacional del Sur. Departamento de Quimica. Instituto de Invest.en Quimica Organica; Argentina. Universitat Zu Koln; Alemania | - |
| dc.description | Fil: Sahl, Hans Georg . Universitat Zu Koln; Alemania | - |
| dc.description | Fil: Benting, Jürgen . Bayer CropScience, Research−Chemistry Disease Control; Alemania | - |
| dc.description | Fil: Nising, Carl F. . Bayer CropScience, Research−Chemistry Disease Control; Alemania | - |
| dc.description | Fil: Hillebrand, Stefan . Bayer CropScience, Research−Chemistry Disease Control; Alemania | - |
| dc.description | Fil: Krönke, Martin. Universitat Zu Koln; Alemania | - |
| dc.description | Fil: Schmalz, Hans-Günther. Universitat Zu Koln; Alemania | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Chemical Society | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/pmid/23905700 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/np400301d | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/10.1021/np400301d | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/np400301d | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/np400301d@proofing | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | PESTALONE | - |
| dc.subject | PESTALACHLORIDE | - |
| dc.subject | ANTIBIOTIC | - |
| dc.subject | BIOLOGICAL ACTIVITY | - |
| dc.subject | Química Orgánica | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | On the Antibiotic and Antifungal Activity of Pestalone, Pestalachloride A, and Structurally Related Compounds | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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