Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Molinero, Luciana Lorena | - |
| dc.creator | Fuertes, Mercedes Beatriz | - |
| dc.creator | Rabinovich, Gabriel Adrián | - |
| dc.creator | Leonardo Fainboim | - |
| dc.creator | Zwirner, Norberto Walter | - |
| dc.date | 2017-12-14T22:27:54Z | - |
| dc.date | 2017-12-14T22:27:54Z | - |
| dc.date | 2002-05 | - |
| dc.date | 2017-12-04T18:00:24Z | - |
| dc.date.accessioned | 2019-04-29T15:46:27Z | - |
| dc.date.available | 2019-04-29T15:46:27Z | - |
| dc.date.issued | 2002-05 | - |
| dc.identifier | Molinero, Luciana Lorena; Fuertes, Mercedes Beatriz; Rabinovich, Gabriel Adrián; Leonardo Fainboim; Zwirner, Norberto Walter; Activation-induced expression of MICA on T lymphocytes involves engagement of CD3 and CD28; Federation of American Societies for Experimental Biology; Journal of Leukocyte Biology; 71; 5; 5-2002; 791-797 | - |
| dc.identifier | 0741-5400 | - |
| dc.identifier | http://hdl.handle.net/11336/30713 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301641 | - |
| dc.description | MICA is an HLA-related cell stress-regulated antigen recognized by cytotoxic cells expressing the NKG2D molecule. Although resting lymphocytes do not express MICA, it can be induced on PHA-activated T cells. Here, we demonstrate by Western blot that MICA is induced on allogeneic-activated CD4(+) and CD8(+) T lymphocytes. Blocking activation with anti-HLA class I, anti-HLA-DR, or anti-CD86 mAb affected the expression of MICA slightly. When T cells were stimulated with anti-CD3 or anti-CD28 mAb plus PMA, a sustained up-regulation of MICA was observed by Western blot, RT-PCR, and flow cytometry. The expression of MICA reached a plateau at day 4 after CD3 engagement and at day 3 after anti-CD28/PMA stimulation. Conversely, the proliferative response reached a peak at day 4. Hence, CD3 or CD28 engagement induces MICA expression on T lymphocytes. This activation-induced expression might participate in NKG2D-mediated cytotoxicity toward activated T cells to maintain homeostasis during an ongoing immune response. | - |
| dc.description | Fil: Molinero, Luciana Lorena. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina | - |
| dc.description | Fil: Fuertes, Mercedes Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina | - |
| dc.description | Fil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Leonardo Fainboim. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina | - |
| dc.description | Fil: Zwirner, Norberto Walter. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Federation of American Societies for Experimental Biology | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.jleukbio.org/content/71/5/791.abstract | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/pmid/11994503 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | MICA | - |
| dc.subject | NKG2D | - |
| dc.subject | T CELLS | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Activation-induced expression of MICA on T lymphocytes involves engagement of CD3 and CD28 | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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