Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Maté, María Laura | - |
| dc.creator | Geary, T. | - |
| dc.creator | Mackenzie, C. | - |
| dc.creator | Lanusse, Carlos Edmundo | - |
| dc.creator | Virkel, Guillermo Leon | - |
| dc.date | 2018-09-06T12:40:06Z | - |
| dc.date | 2018-09-06T12:40:06Z | - |
| dc.date | 2017-10 | - |
| dc.date | 2018-09-05T16:11:28Z | - |
| dc.date.accessioned | 2019-04-29T15:45:44Z | - |
| dc.date.available | 2019-04-29T15:45:44Z | - |
| dc.date.issued | 2017-10 | - |
| dc.identifier | Maté, María Laura; Geary, T.; Mackenzie, C.; Lanusse, Carlos Edmundo; Virkel, Guillermo Leon; Species differences in hepatic biotransformation of the anthelmintic drug flubendazole; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 40; 5; 10-2017; 493-499 | - |
| dc.identifier | 0140-7783 | - |
| dc.identifier | http://hdl.handle.net/11336/58484 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301382 | - |
| dc.description | Flubendazole (FLBZ) is a broad-spectrum benzimidazole anthelmintic used in pigs, poultry, and humans. It has been proposed as a candidate for development for use in elimination programmes for lymphatic filariasis and onchocerciasis in humans. Moreover, FLBZ has shown promise in cancer chemotherapy, particularly for neuroblastoma. This work investigated the hepatic carbonyl-reducing pathway of FLBZ in different species, including humans. Microsomal and cytosolic fractions were obtained from sheep, cattle, pig, hen, rat, and human liver. Both subcellular fractions of each species converted FLBZ into a reduced metabolite (red-FLBZ). The rate of microsomal red-FLBZ production was highest in sheep (1.92 ± 0.13 nmol/min.mg) and lowest in pigs (0.04 ± 0.02 nmol/min.mg); cytosolic red-FLBZ production ranged from 0.02 ± 0.01 (pig) to 1.86 ± 0.61 nmol/min.mg (sheep). Only subcellular fractions from sheep liver oxidized red-FLBZ to FLBZ in a NADP+-dependent oxidative reaction. Liver microsomes from both pigs and humans transformed FLBZ to red-FLBZ and a hydrolyzed metabolite. Very significant differences in the pattern of FLBZ metabolism were observed among the tested species and humans. These results reinforce the need for caution in extrapolating data on metabolism, efficacy, and safety of drugs derived from studies performed in different species. | - |
| dc.description | Fil: Maté, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina | - |
| dc.description | Fil: Geary, T.. McGill University; Canadá | - |
| dc.description | Fil: Mackenzie, C.. Michigan State University; Estados Unidos | - |
| dc.description | Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina | - |
| dc.description | Fil: Virkel, Guillermo Leon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley Blackwell Publishing, Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jvp.12383 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jvp.12383 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | FLUBENDAZOLE | - |
| dc.subject | ANTHELMINTICS | - |
| dc.subject | BIOTRANSFORMATION | - |
| dc.subject | SPECIES DIFFERENCES | - |
| dc.subject | Otras Ciencias Veterinarias | - |
| dc.subject | Ciencias Veterinarias | - |
| dc.subject | CIENCIAS AGRÍCOLAS | - |
| dc.title | Species differences in hepatic biotransformation of the anthelmintic drug flubendazole | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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