Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Sundblad, Victoria | - |
| dc.creator | Morosi, Luciano Gastón | - |
| dc.creator | Geffner, Jorge Raúl | - |
| dc.creator | Rabinovich, Gabriel Adrián | - |
| dc.date | 2018-01-28T12:50:58Z | - |
| dc.date | 2018-01-28T12:50:58Z | - |
| dc.date | 2017-12-01 | - |
| dc.date | 2018-01-12T19:28:22Z | - |
| dc.date.accessioned | 2019-04-29T15:44:17Z | - |
| dc.date.available | 2019-04-29T15:44:17Z | - |
| dc.date.issued | 2018-01-28T12:50:58Z | - |
| dc.date.issued | 2018-01-28T12:50:58Z | - |
| dc.date.issued | 2017-12-01 | - |
| dc.date.issued | 2018-01-12T19:28:22Z | - |
| dc.identifier | Sundblad, Victoria; Morosi, Luciano Gastón; Geffner, Jorge Raúl; Rabinovich, Gabriel Adrián; Galectin-1: A Jack-of-all-trades in the resolution of acute and chronic inflammation; American Association of Immunologists; Journal of Immunology; 199; 11; 1-12-2017; 3721-3730 | - |
| dc.identifier | 0022-1767 | - |
| dc.identifier | http://hdl.handle.net/11336/34812 | - |
| dc.identifier | 1550-6606 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300721 | - |
| dc.description | Regulatory signals provide negative input to immunologicalnetworks promoting resolution of acute andchronic inflammation. Galectin-1 (Gal-1), a member of afamily of evolutionarily conserved glycan-binding proteins,displays broad anti-inflammatory and proresolvingactivities by targeting multiple immune cell types. Withinthe innate immune compartment, Gal-1 acts as a resolutionassociatedmolecular pattern by counteracting the synthesisof proinflammatory cytokines, inhibiting neutrophiltrafficking, targeting eosinophil migration and survival,and suppressing mast cell degranulation. Likewise, thislectin controls T cell and B cell compartments by modulatingreceptor clustering and signaling, thus serving asa negative-regulatory checkpoint that reprograms cellularactivation, differentiation, and survival. In this review,we discuss the central role of Gal-1 in regulatoryprograms operating during acute inflammation, autoimmunediseases, allergic inflammation, pregnancy, cancer,and infection. Therapeutic strategies aimed at targetingGal-1?glycan interactions will contribute to overcomecancer immunosuppression and reinforce antimicrobialimmunity, whereas stimulation of Gal-1?driven immunoregulatorycircuits will help to mitigate exuberant inflammation. | - |
| dc.description | Fil: Sundblad, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Morosi, Luciano Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina | - |
| dc.description | Fil: Geffner, Jorge Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina | - |
| dc.description | Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Association of Immunologists | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.jimmunol.org/content/199/11/3721.long | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4049/jimmunol.1701172 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/pmid/29158348 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/34812 | - |
| dc.subject | GALECTIN-1 | - |
| dc.subject | IMMUNOMODULATION | - |
| dc.subject | INFLAMMATION | - |
| dc.subject | RESOLUTION | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Galectin-1: A Jack-of-all-trades in the resolution of acute and chronic inflammation | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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