Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Pomares, Maria Fernanda | - |
| dc.creator | Delgado, Monica Alejandra | - |
| dc.creator | Corbalan, Natalia Soledad | - |
| dc.creator | Farias, Ricardo Norberto | - |
| dc.creator | Vincent, Paula Andrea | - |
| dc.date | 2018-10-22T22:30:45Z | - |
| dc.date | 2018-10-22T22:30:45Z | - |
| dc.date | 2010-10 | - |
| dc.date | 2018-10-17T15:03:56Z | - |
| dc.date.accessioned | 2019-04-29T15:43:41Z | - |
| dc.date.available | 2019-04-29T15:43:41Z | - |
| dc.date.issued | 2018-10-22T22:30:45Z | - |
| dc.date.issued | 2018-10-22T22:30:45Z | - |
| dc.date.issued | 2010-10 | - |
| dc.date.issued | 2018-10-17T15:03:56Z | - |
| dc.identifier | Pomares, Maria Fernanda; Delgado, Monica Alejandra; Corbalan, Natalia Soledad; Farias, Ricardo Norberto; Vincent, Paula Andrea; Sensitization of microcin J25-resistant strains by a membrane-permeabilizing peptide; American Society for Microbiology; Applied And Environmental Microbiology; 76; 20; 10-2010; 6837-6842 | - |
| dc.identifier | 0099-2240 | - |
| dc.identifier | http://hdl.handle.net/11336/62917 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300460 | - |
| dc.description | Microcin J25 (MccJ25) is a plasmid-encoded, 21-amino-acid, antibacterial peptide produced by Escherichia coli. MccJ25 inhibits RNA polymerase and the membrane respiratory chain. MccJ25 uptake into E. colisensitive strains is mediated by the outer membrane receptor FhuA and the inner membrane proteins TonB, ExbB, ExbD, and SbmA. This peptide is active on some E. coli, Salmonella, and Shigella species strains, while other Gram-negative bacteria, such as clinical isolates of Enterobacter cloacae, Citrobacter freundii, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Moraxella catarrhalis, and Salmonella enterica serovar Typhimurium, are completely resistant. In the present work, we demonstrated that the membranepermeabilizing peptide (KFF)3K made some resistant strains sensitive to MccJ25, among them S. Typhimurium, where the antibiotic inhibits in vitro cell growth and bacterial replication within macrophages. The results demonstrate that the membrane permeabilization induced by (KFF)3K allows MccJ25 penetration in an FhuA and SbmA-independent manner and suggest that the combination of both peptides could be considered as a therapeutic agent against pathogenic Salmonella strains. | - |
| dc.description | Fil: Pomares, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina | - |
| dc.description | Fil: Delgado, Monica Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina | - |
| dc.description | Fil: Corbalan, Natalia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina | - |
| dc.description | Fil: Farias, Ricardo Norberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina | - |
| dc.description | Fil: Vincent, Paula Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Society for Microbiology | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://aem.asm.org/content/76/20/6837 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/ 10.1128/AEM.00307-10 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | microcin J25 | - |
| dc.subject | antibiotic | - |
| dc.subject | membrane-permeabilizing peptide. | - |
| dc.subject | E coli | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Sensitization of microcin J25-resistant strains by a membrane-permeabilizing peptide | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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