Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Bublik, Débora Rosa | - |
| dc.creator | Scolz, Massimiliano | - |
| dc.creator | Triolo, Gianluca | - |
| dc.creator | Monte, Martin | - |
| dc.creator | Schneider, Claudio | - |
| dc.date | 2018-12-18T18:06:06Z | - |
| dc.date | 2018-12-18T18:06:06Z | - |
| dc.date | 2010-02 | - |
| dc.date | 2018-11-22T15:28:41Z | - |
| dc.date.accessioned | 2019-04-29T15:43:04Z | - |
| dc.date.available | 2019-04-29T15:43:04Z | - |
| dc.date.issued | 2010-02 | - |
| dc.identifier | Bublik, Débora Rosa; Scolz, Massimiliano; Triolo, Gianluca; Monte, Martin; Schneider, Claudio; Human GTSE-1 regulates p21CIP1/WAF1 stability conferring resistance to paclitaxel treatment; American Society for Biochemistry and Molecular Biology; Journal of Biological Chemistry (online); 285; 8; 2-2010; 5274-5281 | - |
| dc.identifier | 0021-9258 | - |
| dc.identifier | http://hdl.handle.net/11336/66674 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300246 | - |
| dc.description | p21CIP1/WAF1 belongs to the CIP/KIP family of Cdk inhibitors, and its expression is tightly controlled during the cell cycle, mainly by transcriptional and post-translational mechanisms. Fine regulation of p21 CIP1/WAF1 levels is critical for cell cycle control and for cellular response to stress. In the present work, we describe a novel mechanism to modulate p21CIP1/WAF1 levels mediated by the human GTSE-1 (G 2 and S phase-expressed-1) protein. Our results provide evidence that hGTSE-1 protects p21CIP1/WAF1 from proteasome-dependent degradation as part of a functional complex containing the Hsp90-bindingTPR protein WISp39. We further show that the hGTSE-1 N-terminal portion is sufficient for p21 CIP1/WAF1 binding and stabilization. Finally, we demonstrate that hGTSE-1 mediated-p21CIP1/WAF1 stabilization is clearly involved in the ability of cells to counter-act cytotoxicity induced by the microtubule poison paclitaxel. © 2010 by The American Society for Biochemistry and Molecular Biology, Inc. | - |
| dc.description | Fil: Bublik, Débora Rosa. Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie ; Italia | - |
| dc.description | Fil: Scolz, Massimiliano. Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie ; Italia | - |
| dc.description | Fil: Triolo, Gianluca. Genome Stability Laboratory; Italia | - |
| dc.description | Fil: Monte, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie ; Italia | - |
| dc.description | Fil: Schneider, Claudio. Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie ; Italia. Università di Udine; Italia | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Society for Biochemistry and Molecular Biology | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1074/jbc.M109.045948 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.jbc.org/content/285/8/5274 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | GTSE | - |
| dc.subject | p21 | - |
| dc.subject | taxol | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Human GTSE-1 regulates p21CIP1/WAF1 stability conferring resistance to paclitaxel treatment | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.