1. RODNA
  2. CONICET
  3. CONICET
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.provenanceCONICET-
dc.creatorAcevedo, María E.-
dc.creatorFernandez, Adriana-
dc.creatorPasquali, Ricardo C.-
dc.creatorSorichetti, Patricia A.-
dc.creatorSerrao, Rosa-
dc.creatorBregni, Carlos-
dc.creatorMouriño, Viviana Silvia Lourdes-
dc.date2017-02-22T19:41:42Z-
dc.date2017-02-22T19:41:42Z-
dc.date2011-09-
dc.date2017-02-15T14:09:24Z-
dc.date.accessioned2019-04-29T15:41:27Z-
dc.date.available2019-04-29T15:41:27Z-
dc.date.issued2017-02-22T19:41:42Z-
dc.date.issued2017-02-22T19:41:42Z-
dc.date.issued2011-09-
dc.date.issued2017-02-15T14:09:24Z-
dc.identifierAcevedo, María E.; Fernandez, Adriana; Pasquali, Ricardo C.; Sorichetti, Patricia A.; Serrao, Rosa; et al.; Solubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation Developments; Colegio Farmaceuticos Provincia de Buenos Aires; Latin American Journal of Pharmacy; 30; 9; 9-2011; 1737-1743-
dc.identifier0326-2383-
dc.identifierhttp://hdl.handle.net/11336/13324-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299619-
dc.descriptionNon-irritant, non-comedogenic and non-polar emollients were pre-selected for determinations of relative dielectric permittivity and solubility of benzoyl peroxide (BP). Those solvents capable of solubilizing BP in concentrations commonly utilised in topical formulations (between 1 and 10 %) were taken into account for stability studies. The developed pre-formulations were also studied for acute irritation both clinically and instrumentally. Even though the solubility of BP in the solvents studied had relatively low values; in some cases, such as with caprylic/capric triglyceride (CapCap) and dicaprylyl carbonate (DicCar) it has been possible to obtain acceptable concentrations of BP from a therapeutic viewpoint (19.9 and 19.5 mg/mL, respectively). Two BP pre-formulations (PBCapCap and PBDicCar) with enhanced stability and with the capability to decrease adverse application site reaction by maintaining moisture in the stratum corneum were developed with potential application in topical formulations of BP with solvents of low relative dielectric permittivity (CapCap and DicCar, respectively-
dc.descriptionFil: Acevedo, María E.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina-
dc.descriptionFil: Fernandez, Adriana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina-
dc.descriptionFil: Pasquali, Ricardo C.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina-
dc.descriptionFil: Sorichetti, Patricia A.. Universidad de Buenos Aires. Facultad de Ingenieria. Departamento de Fisica; Argentina-
dc.descriptionFil: Serrao, Rosa. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina-
dc.descriptionFil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina-
dc.descriptionFil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Imperial College London; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherColegio Farmaceuticos Provincia de Buenos Aires-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/previous_issue.php?vol=30&num=9-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/30560-
dc.subjectBenzoyl peroxide-
dc.subjectPre-formulation-
dc.subjectSolubility-
dc.subjectStability-
dc.subjectThermodynamic activity-
dc.subjectFísico-Química, Ciencia de los Polímeros, Electroquímica-
dc.subjectCiencias Químicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleSolubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation Developments-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
Aparece en las colecciones: CONICET

Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro sencillo del ítem