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dc.creatorHuhtaniemi, Ilpo-
dc.creatorAhtiainen, Petteri-
dc.creatorPakarainen, Tomi-
dc.creatorRulli, Susana Beatriz-
dc.creatorZhang, Fu Ping-
dc.creatorPoutanen, Mattu-
dc.date2017-06-21T14:48:06Z-
dc.date2017-06-21T14:48:06Z-
dc.date2006-06-27-
dc.date2017-05-16T20:33:11Z-
dc.date.accessioned2019-04-29T15:41:02Z-
dc.date.available2019-04-29T15:41:02Z-
dc.date.issued2017-06-21T14:48:06Z-
dc.date.issued2017-06-21T14:48:06Z-
dc.date.issued2006-06-27-
dc.date.issued2017-05-16T20:33:11Z-
dc.identifierHuhtaniemi, Ilpo; Ahtiainen, Petteri; Pakarainen, Tomi; Rulli, Susana Beatriz; Zhang, Fu Ping; et al.; Genetically modified mouse models in studies of luteinising hormone action; Elsevier Ireland; Molecular And Cellular Endocrinology; 252; 1-2; 27-6-2006; 126-135-
dc.identifier0303-7207-
dc.identifierhttp://hdl.handle.net/11336/18519-
dc.identifier1872-8057-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299439-
dc.descriptionNumerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-alpha(Calpha), luteinising hormone (LH) beta and follicle-stimulating hormone (FSH) beta subunits, and the two gonadotrophin receptors (R), LHR and FSHR. In addition, there are also transgenic (TG) mice overexpressing gonadotrophin subunits and producing supraphysiological levels of these hormones. These models have offered relevant phenocopies for similar mutations in humans and to a great extent expanded our knowledge on normal and pathological functions of the hypothalamic-pituitary-gonadal (HPG) axis. The purpose of this article is to review some of our recent findings on two such mouse models, the LHR KO mouse (LuRKO), and the hCG overexpressing TG mouse (hCG+).-
dc.descriptionFil: Huhtaniemi, Ilpo. Imperial College London; Reino Unido. University of Turku; Finlandia-
dc.descriptionFil: Ahtiainen, Petteri. University of Turku; Finlandia-
dc.descriptionFil: Pakarainen, Tomi. University of Turku; Finlandia-
dc.descriptionFil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina-
dc.descriptionFil: Zhang, Fu Ping. University of Helsinki; Finlandia-
dc.descriptionFil: Poutanen, Mattu. University of Turku; Finlandia-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherElsevier Ireland-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720706001213-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mce.2006.03.026-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectLUTEINISING HORMONE-
dc.subjectCHORIOGONADOTROPHIN-
dc.subjectLH RECEPTOR-
dc.subjectKNOCK-OUT MICE-
dc.subjectTRANSGENIC MICE-
dc.subjectFisiología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleGenetically modified mouse models in studies of luteinising hormone action-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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