Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Chattah, Ana Karina | - |
| dc.creator | Zhang, Rongchun | - |
| dc.creator | Mroue, Kamal H. | - |
| dc.creator | Pfund, Laura | - |
| dc.creator | Longhi, Marcela Raquel | - |
| dc.creator | Ramamoorthy, Ayyalusamy | - |
| dc.creator | Garnero, Claudia | - |
| dc.date | 2018-07-11T14:40:19Z | - |
| dc.date | 2018-07-11T14:40:19Z | - |
| dc.date | 2015-03 | - |
| dc.date | 2018-07-04T14:38:22Z | - |
| dc.date.accessioned | 2019-04-29T15:40:46Z | - |
| dc.date.available | 2019-04-29T15:40:46Z | - |
| dc.date.issued | 2018-07-11T14:40:19Z | - |
| dc.date.issued | 2018-07-11T14:40:19Z | - |
| dc.date.issued | 2015-03 | - |
| dc.date.issued | 2018-07-04T14:38:22Z | - |
| dc.identifier | Chattah, Ana Karina; Zhang, Rongchun; Mroue, Kamal H.; Pfund, Laura; Longhi, Marcela Raquel; et al.; Investigating Albendazole Desmotropes by Solid-State NMR Spectroscopy; American Chemical Society; Molecular Pharmaceutics; 12; 3; 3-2015; 731-741 | - |
| dc.identifier | 1543-8384 | - |
| dc.identifier | http://hdl.handle.net/11336/51721 | - |
| dc.identifier | 1543-8392 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/299320 | - |
| dc.description | Characterization of the molecular structure and physicochemical solid-state properties of the solid forms of pharmaceutical compounds is a key requirement for successful commercialization as potential active ingredients in drug products. These properties can ultimately have a critical effect on the solubility and bioavailability of the final drug product. Here, the desmotropy of Albendazole forms I and II was investigated at the atomic level. Ultrafast magic angle spinning (MAS) solid-state nuclear magnetic resonance (NMR) spectroscopy, together with powder X-ray diffraction, thermal analysis, and Fourier transform infrared spectroscopy, were performed on polycrystalline samples of the two solids in order to fully characterize and distinguish the two forms. High-resolution one-dimensional 1H, 13C, and 15N together with two-dimensional 1H/1H single quantum-single quantum, 1H/1H single quantum-double quantum, and 1H/13C chemical shift correlation solid-state NMR experiments under MAS conditions were extensively used to decipher the intramolecular and intermolecular hydrogen bonding interactions present in both solid forms. These experiments enabled the unequivocal identification of the tautomers of each desmotrope. Our results also revealed that both solid forms may be described as dimeric structures, with different intermolecular hydrogen bonds connecting the tautomers in each dimer. | - |
| dc.description | Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina | - |
| dc.description | Fil: Zhang, Rongchun. University of Michigan; Estados Unidos | - |
| dc.description | Fil: Mroue, Kamal H.. University of Michigan; Estados Unidos | - |
| dc.description | Fil: Pfund, Laura. University of Michigan; Estados Unidos | - |
| dc.description | Fil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina | - |
| dc.description | Fil: Ramamoorthy, Ayyalusamy. University of Michigan; Estados Unidos | - |
| dc.description | Fil: Garnero, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Chemical Society | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/mp500539g | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/mp500539g | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | ALBENDAZOLE | - |
| dc.subject | CHARACTERIZATION | - |
| dc.subject | DESMOTROPY | - |
| dc.subject | RFDR | - |
| dc.subject | SOLID-STATE NMR | - |
| dc.subject | TAUTOMERISM | - |
| dc.subject | ULTRAFAST MAS | - |
| dc.subject | Nano-materiales | - |
| dc.subject | Nanotecnología | - |
| dc.subject | INGENIERÍAS Y TECNOLOGÍAS | - |
| dc.title | Investigating Albendazole Desmotropes by Solid-State NMR Spectroscopy | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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