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dc.provenanceCONICET-
dc.creatorLeal Reyna, Mariela-
dc.creatorGomez, Reynaldo Manuel-
dc.creatorLupi, Susana N.-
dc.creatorBelli, Susana H.-
dc.creatorFenili, Cecilia A.-
dc.creatorMartínez, Marcela S.-
dc.creatorRuibal, Gabriela F.-
dc.creatorRossi, María A-
dc.creatorChervin, Raúl A-
dc.creatorCornaló, Dora-
dc.creatorContreras, Liliana Noemí-
dc.creatorCosta, Liliana-
dc.creatorNofal, María T.-
dc.creatorDamilano, Sergio A.-
dc.creatorPardes, Ester M.-
dc.date2018-04-17T18:24:44Z-
dc.date2018-04-17T18:24:44Z-
dc.date2015-10-
dc.date2018-04-13T14:32:53Z-
dc.date.accessioned2019-04-29T15:39:20Z-
dc.date.available2019-04-29T15:39:20Z-
dc.date.issued2015-10-
dc.identifierLeal Reyna, Mariela; Gomez, Reynaldo Manuel; Lupi, Susana N.; Belli, Susana H.; Fenili, Cecilia A.; et al.; Screening for primary aldosteronism in an argentinian population: a multicenter prospective study; SP SegmentoFarma Editores; Archives of Endocrinology and Metabolism; 59; 5; 10-2015; 441-447-
dc.identifier2359-3997-
dc.identifierhttp://hdl.handle.net/11336/42343-
dc.identifier2359-4292-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298679-
dc.descriptionOBJECTIVES:Primary aldosteronism (PA) is characterized by the autonomous overproduction of aldosterone. Its prevalence has increased since the use of the aldosterone (ALD)/plasma renin activity (PRA) ratio (ARR). The objective of this study is to determine ARR and ARC (ALD/plasma renin concentration ratio) cut-off values (COV) and their diagnostic concordance (DC%) in the screening for PA in an Argentinian population.Design multicenter prospective study.SUBJECTS AND METHODS:We studied 353 subjects (104 controls and 249 hypertensive patients). Serum aldosterone, PRA and ARR were determined. In 220 randomly selected subjects, 160 hypertensive patients and 60 controls, plasma renin concentration (PRC) was simultaneously measured and ARC was determined.RESULTS:According to the 95th percentile of controls, we determined a COV of 36 for ARR and 2.39 for ARC, with ALD ≥ 15 ng/dL. In 31/249 hypertensive patients, ARR was ≥ 36. PA diagnosis was established in 8/31 patients (23/31 patients did not complete confirmatory tests). DC% between ARR and ARC was calculated. A significant correlation between ARR and ARC (r = 0.742; p < 0.0001) was found only with PRA > 0.3 ng/mL/h and PRC > 5 pg/mL. DC% for ARR and ARC above or below 36 and 2.39 was 79.1%, respectively.CONCLUSION:This first Argentinian multicenter study determined a COV of 36 for ARR and 2.39 for ARC. Applying an ARR ≥ 36 in the hypertensive group, we confirmed PA in a higher percentage of patients than the previously reported one in our population. As for ARC, further studies are needed for its clinical application, since DC% is acceptable only for medium range renin values.-
dc.descriptionFil: Leal Reyna, Mariela. Gobierno de la Ciudad Autónoma de Buenos Aires. Complejo Médico Churruca Visca; Argentina-
dc.descriptionFil: Gomez, Reynaldo Manuel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina-
dc.descriptionFil: Lupi, Susana N.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina-
dc.descriptionFil: Belli, Susana H.. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital C. Durand; Argentina-
dc.descriptionFil: Fenili, Cecilia A.. Gobierno de la Ciudad Autónoma de Buenos Aires. Laboratorio Bioanalítica; Argentina-
dc.descriptionFil: Martínez, Marcela S.. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital C. Milstein; Argentina-
dc.descriptionFil: Ruibal, Gabriela F.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina-
dc.descriptionFil: Rossi, María A. Gobierno de la Ciudad Autónoma de Buenos Aires. Complejo Médico Churruca Visca; Argentina-
dc.descriptionFil: Chervin, Raúl A. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina-
dc.descriptionFil: Cornaló, Dora. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital B. Rivadavia; Argentina-
dc.descriptionFil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina-
dc.descriptionFil: Costa, Liliana. Gobierno de la Provincia de Buenos Aires. Hospital Nacional “Profesor Alejandro Posadas” ; Argentina-
dc.descriptionFil: Nofal, María T.. Clínica Bazterrica; Argentina-
dc.descriptionFil: Damilano, Sergio A.. Laboratorio Bioanalítica; Argentina-
dc.descriptionFil: Pardes, Ester M.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/vnd.openxmlformats-officedocument.wordprocessingml.document-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherSP SegmentoFarma Editores-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/mjqbzf-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1590/2359-3997000000075-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/42343-
dc.subjectPRIMARY ALDOSTERONISM-
dc.subjectALDOSTERONE-
dc.subjectHYPERTENSION-
dc.subjectMedicina Critica y de Emergencia-
dc.subjectMedicina Clínica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleScreening for primary aldosteronism in an argentinian population: a multicenter prospective study-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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