Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Gatica, Eduardo Antonio | - |
| dc.creator | Natera, Jose Eduardo | - |
| dc.creator | Pajares, Adriana Mabel | - |
| dc.creator | Gambetta, Carolina | - |
| dc.creator | Sancho, Matias Israel | - |
| dc.creator | Massad, Walter Alfredo | - |
| dc.creator | Garcia, Norman Andino | - |
| dc.date | 2018-03-12T18:54:07Z | - |
| dc.date | 2018-03-12T18:54:07Z | - |
| dc.date | 2017-11 | - |
| dc.date | 2018-03-09T18:59:27Z | - |
| dc.date.accessioned | 2019-04-29T15:39:12Z | - |
| dc.date.available | 2019-04-29T15:39:12Z | - |
| dc.date.issued | 2017-11 | - |
| dc.identifier | Gatica, Eduardo Antonio; Natera, Jose Eduardo; Pajares, Adriana Mabel; Gambetta, Carolina; Sancho, Matias Israel; et al.; Cyclodextrine-nanoencapsulation of niclosamide: Water solubility and meaningful enhancement of visible-light—Mediated sensitized photodegradation of the drug; Elsevier Science Sa; Journal of Photochemistry and Photobiology A: Chemistry; 348; 11-2017; 295-304 | - |
| dc.identifier | 1010-6030 | - |
| dc.identifier | http://hdl.handle.net/11336/38557 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298618 | - |
| dc.description | A kinetic and mechanistic study of the daylight-mediated photooxidation of the multifunctional drug Niclosamide (NSD) was carried out in aqueous solutions. NSD is a frequent contaminant suspended in natural waters. The aqueous dissolution of the practically insoluble NSD was driven by the presence of 2-hydrxypropyl-β-cyclodextrin (HPβCD). The already proposed formation of an inclusion complex between NSD-HPβCD was confirmed through theoretical studies. NSD-nanoencapsulation within the oligosaccharide occurs with a 1:2 stoichiometry, being the drug embedded into a cavity of two HPβCD molecules, in a so called head-to-head orientation. The Reactive Oxygen Species singlet molecular oxygen, superoxide radical anion and hydrogen peroxide, generated through the visible-light absorber sensitizers Riboflavin and Rose Bengal, are effectively intercepted by the encapsulated biocide and contribute to its photodegradation. The overall NSD photooxidation rate, determined through oxygen consumption indicates that the process is relatively highly efficient in the microheterogeneous aqueous media as compared to NSD in MeOH solution, and to phenol (PHE) in pure water. The paradigmatic water-contaminant PHE was taken a as reference in order to evaluate the persistence of the NSD under photosensitized irradiation in aqueous medium. The photooxidation mechanism of NSD is affected by cyclodextrin complexation, due to dynamic limitations, electrostatic interactions and pH changes upon NSD dissolution in aqueous HPβCD. In this sense, the NSD-HPβCD complex can be seen as a sort of nanoreactor that enables the photodegradation of the biocide in water, under daylight conditions. | - |
| dc.description | Fil: Gatica, Eduardo Antonio. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina | - |
| dc.description | Fil: Natera, Jose Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina | - |
| dc.description | Fil: Pajares, Adriana Mabel. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ingeniería - Sede Comodoro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Patagonia Austral. Unidad Académica Río Gallegos; Argentina | - |
| dc.description | Fil: Gambetta, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina | - |
| dc.description | Fil: Sancho, Matias Israel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina | - |
| dc.description | Fil: Massad, Walter Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina | - |
| dc.description | Fil: Garcia, Norman Andino. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Science Sa | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1010603017306457 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jphotochem.2017.08.015 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/38557 | - |
| dc.subject | CYCLODEXTRIN ENCAPSULATION | - |
| dc.subject | NICLOSAMIDE | - |
| dc.subject | PHOTOOXIDATION | - |
| dc.subject | PHOTOSENSITIZATION | - |
| dc.subject | REACTIVE OXYGEN SPECIES | - |
| dc.subject | RIBOFLAVIN | - |
| dc.subject | Otras Ciencias Químicas | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Cyclodextrine-nanoencapsulation of niclosamide: Water solubility and meaningful enhancement of visible-light—Mediated sensitized photodegradation of the drug | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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