Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Oliveira, Mayara | - |
| dc.creator | Gomes Alves, Ana G. | - |
| dc.creator | Sousa, Carla | - |
| dc.creator | Marani, Mariela Mirta | - |
| dc.creator | Plácido, Alexandra | - |
| dc.creator | Vale, Nuno | - |
| dc.creator | Delerue Matos, Cristina | - |
| dc.creator | Gameiro, Paula | - |
| dc.creator | Kückelhaus, Selma A. S. | - |
| dc.creator | Tomas, Ana M. | - |
| dc.creator | Leite, José Roberto de Souza Almeida | - |
| dc.creator | Eaton, Peter | - |
| dc.date | 2018-03-21T14:45:15Z | - |
| dc.date | 2018-03-21T14:45:15Z | - |
| dc.date | 2016-12 | - |
| dc.date | 2018-03-12T14:23:54Z | - |
| dc.date.accessioned | 2019-04-29T15:38:50Z | - |
| dc.date.available | 2019-04-29T15:38:50Z | - |
| dc.date.issued | 2016-12 | - |
| dc.identifier | Oliveira, Mayara; Gomes Alves, Ana G.; Sousa, Carla; Marani, Mariela Mirta; Plácido, Alexandra; et al.; Ocellatin-PT antimicrobial peptides: High-resolution microscopy studies in antileishmania models and interactions with mimetic membrane systems; John Wiley & Sons Inc; Biopolymers; 105; 12; 12-2016; 873-886 | - |
| dc.identifier | 0006-3525 | - |
| dc.identifier | http://hdl.handle.net/11336/39471 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/298462 | - |
| dc.description | Although the mechanism of action of antimicrobial peptides (AMPs) is not clear, they can interact electrostatically with the cell membranes of microorganisms. New ocellatin‐PT peptides were recently isolated from the skin secretion of Leptodactylus pustulatus. The secondary structure of these AMPs and their effect on Leishmania infantum cells, and on different lipid surface models was characterized in this work. The results showed that all ocellatin‐PT peptides have an α‐helix structure and five of them (PT3, PT4, PT6 to PT8) have leishmanicidal activity; PT1 and PT2 affected the cellular morphology of the parasites and showed greater affinity for leishmania and bacteria‐mimicking lipid membranes than for those of mammals. The results show selectivity of ocellatin‐PTs to the membranes of microorganisms and the applicability of biophysical methods to clarify the interaction of AMPs with cell membranes. | - |
| dc.description | Fil: Oliveira, Mayara. Universidade do Brasília; Brasil. Universidad de Porto; Portugal | - |
| dc.description | Fil: Gomes Alves, Ana G.. Universidad de Porto; Portugal. Universidade Do Minho; Portugal | - |
| dc.description | Fil: Sousa, Carla. Universidad de Porto; Portugal | - |
| dc.description | Fil: Marani, Mariela Mirta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; Argentina | - |
| dc.description | Fil: Plácido, Alexandra. Instituto Politécnico do Porto; Portugal | - |
| dc.description | Fil: Vale, Nuno. Universidad de Porto; Portugal | - |
| dc.description | Fil: Delerue Matos, Cristina. Instituto Politécnico do Porto; Portugal | - |
| dc.description | Fil: Gameiro, Paula. Universidad de Porto; Portugal | - |
| dc.description | Fil: Kückelhaus, Selma A. S.. Universidade do Brasília; Brasil | - |
| dc.description | Fil: Tomas, Ana M.. Universidad de Porto; Portugal | - |
| dc.description | Fil: Leite, José Roberto de Souza Almeida. Universidad de Porto; Portugal. Universidade do Brasília; Brasil. Universidade Federal do Piauí; Brasil | - |
| dc.description | Fil: Eaton, Peter. Universidad de Porto; Portugal. Universidade Federal do Piauí; Brasil | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | John Wiley & Sons Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/bip.22925 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/bip.22925 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/39471 | - |
| dc.subject | ANTIMICROBIAL PEPTIDES | - |
| dc.subject | ATOMIC FORCE MICROSCOPY | - |
| dc.subject | LEISHMANIA INFANTUM | - |
| dc.subject | LIPID MEMBRANES | - |
| dc.subject | SCANNING ELECTRON MICROSCOPY | - |
| dc.subject | SURFACE PLASMON RESONANCE | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Ocellatin-PT antimicrobial peptides: High-resolution microscopy studies in antileishmania models and interactions with mimetic membrane systems | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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