Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Villalba, Maria Luisa | - |
| dc.creator | Palestro, Pablo Hernán | - |
| dc.creator | Ceruso, Mariangela | - |
| dc.creator | Talevi, Alan | - |
| dc.creator | Gonzalez Funes, Jose L. | - |
| dc.creator | Bruno Blanch, Luis Enrique | - |
| dc.creator | Supuran, Claudiu T. | - |
| dc.creator | Gavernet, Luciana | - |
| dc.date | 2017-09-20T20:06:16Z | - |
| dc.date | 2017-09-20T20:06:16Z | - |
| dc.date | 2016-02-15 | - |
| dc.date | 2017-09-19T14:17:44Z | - |
| dc.date.accessioned | 2019-04-29T15:36:50Z | - |
| dc.date.available | 2019-04-29T15:36:50Z | - |
| dc.date.issued | 2016-02-15 | - |
| dc.identifier | Villalba, Maria Luisa; Palestro, Pablo Hernán; Ceruso, Mariangela; Talevi, Alan; Gonzalez Funes, Jose L.; et al.; Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action; Pergamon-Elsevier Science Ltd.; Bioorganic & Medicinal Chemistry; 24; 4; 15-2-2016; 894-901 | - |
| dc.identifier | 0968-0896 | - |
| dc.identifier | http://hdl.handle.net/11336/24743 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297767 | - |
| dc.description | A set of N,N0 -disubstituted sulfamides and sodium cyclamate have been tested for their inhibitory action against six isoforms of carbonic anhydrase (CA, EC 4.2.1.1) found in the brain, that is, CA I, CA II, CA VII, CA IX, CA XII and CA XIV, some of which are involved in epileptogenesis. The biological data showed interesting results for CA VII inhibition, the isozyme thought to be a novel antiepileptic target. Strong CA VII inhibitors, with Ki values in the low nanomolar–subnanomolar range were identified. Some of these derivatives showed selectivity for inhibition of CA VII versus the ubiquitous isoform CA II, for which the Ki values were in the micromolar range. Molecular modeling approaches were employed to understand the binding interactions between these compounds and the two CA isoforms, since the mechanism of action of such disubstituted sulfamides was not yet investigated by means of X-ray crystallography | - |
| dc.description | Fil: Villalba, Maria Luisa. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina | - |
| dc.description | Fil: Palestro, Pablo Hernán. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Ceruso, Mariangela. Universita Degli Studi Di Firenze; Italia | - |
| dc.description | Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Gonzalez Funes, Jose L.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina | - |
| dc.description | Fil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Supuran, Claudiu T.. Universita Degli Studi Di Firenze; Italia | - |
| dc.description | Fil: Gavernet, Luciana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Pergamon-Elsevier Science Ltd. | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.journals.elsevier.com/bioorganic-and-medicinal-chemistry/ | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bmc.2016.01.012 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/24743 | - |
| dc.subject | Carbonic anhydrase | - |
| dc.subject | Sulfamides | - |
| dc.subject | Docking | - |
| dc.subject | Epilepsy | - |
| dc.subject | Sodium cyclamate | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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