Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Luster, Brennon | - |
| dc.creator | D'Onofrio, Stasia | - |
| dc.creator | Urbano Suarez, Francisco Jose | - |
| dc.creator | Garcia Rill, Edgar | - |
| dc.date | 2018-09-21T18:49:59Z | - |
| dc.date | 2018-09-21T18:49:59Z | - |
| dc.date | 2015-07 | - |
| dc.date | 2018-09-19T14:33:30Z | - |
| dc.date.accessioned | 2019-04-29T15:36:47Z | - |
| dc.date.available | 2019-04-29T15:36:47Z | - |
| dc.date.issued | 2015-07 | - |
| dc.identifier | Luster, Brennon; D'Onofrio, Stasia; Urbano Suarez, Francisco Jose; Garcia Rill, Edgar; High-Threshold Ca2+ channels behind gamma band activity in the pedunculopontine nucleus (PPN); American Physiological Society and The Physiological Society; Physiological Reports; 3; 6; 7-2015; 1-11 | - |
| dc.identifier | 2051-817X | - |
| dc.identifier | http://hdl.handle.net/11336/60608 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297756 | - |
| dc.description | The pedunculopontine nucleus (PPN) is part of the Reticular Activating System, and active during waking and REM sleep. Previous results showed that all PPN cells plateau at gamma frequencies and intrinsic membrane oscillations in PPN neuons are mediated by high threshold N- and P/Q-type Ca2+ channels. The present study was designed to determine whether some PPN cells have only N-, only P/Q-, or both N- and P/Q-type Ca2+ channels. We used patch clamp recordings in PPN cells in slices from anesthetized rat pups in the presence of synaptic receptor blockers (SB) and Tetrodotoxin (TTX), and applied ramps to induce intrinsic membrane oscillations. We found that all PPN cell types showed gamma oscillations in the presence of SB+TTX when using current ramps. In 50% of cells, the N-type Ca2+ channel blocker ω-Conotoxin-GVIA (ω-CgTx) reduced gamma oscillation amplitude, while subsequent addition of the P/Q-type blocker ω- Agatoxin-IVA (ω-Aga) blocked the remaining oscillations. Another 20% manifested gamma oscillations that were not significantly affected by the addition of ω-CgTx, however, ω-Aga blocked the remaining oscillations. In 30% of cells, ω-Aga had no effect on gamma oscillations, while ω-CgTx blocked them. These novel results confirm the segregation of populations of PPN cells as a function of the calcium channels expressed, i.e. the presence of cells in the PPN that manifest gamma band oscillations through only N-type, only P/Q-type, and both N-type and P/Q-type Ca2+ channels. | - |
| dc.description | Fil: Luster, Brennon. Center For Translational Neuroscience; Estados Unidos | - |
| dc.description | Fil: D'Onofrio, Stasia. Center For Translational Neuroscience; Estados Unidos | - |
| dc.description | Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina | - |
| dc.description | Fil: Garcia Rill, Edgar. Center For Translational Neuroscience; Estados Unidos | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Physiological Society and The Physiological Society | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://physoc.onlinelibrary.wiley.com/doi/abs/10.14814/phy2.12431 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/10.14814.phy2.12431 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510632/ | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/60608 | - |
| dc.subject | AROUSAL | - |
| dc.subject | GAMMA OSCILLATIONS | - |
| dc.subject | N-TYPE CALCIUM CHANNELS | - |
| dc.subject | P/Q-TYPE CALCIUM CHANNELS | - |
| dc.subject | PEDUNCULOPONTINE | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | High-Threshold Ca2+ channels behind gamma band activity in the pedunculopontine nucleus (PPN) | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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