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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Alberton, Kese Pontes Freitas | - |
| dc.creator | Alberton, André Luís | - |
| dc.creator | Di Maggio, Jimena Andrea | - |
| dc.creator | Estrada, Vanina Gisela | - |
| dc.creator | Díaz, María Soledad | - |
| dc.creator | Resende Secchi, Argimiro | - |
| dc.date | 2017-09-18T15:13:46Z | - |
| dc.date | 2017-09-18T15:13:46Z | - |
| dc.date | 2015-02 | - |
| dc.date | 2017-05-02T20:15:44Z | - |
| dc.date.accessioned | 2019-04-29T15:34:48Z | - |
| dc.date.available | 2019-04-29T15:34:48Z | - |
| dc.date.issued | 2017-09-18T15:13:46Z | - |
| dc.date.issued | 2017-09-18T15:13:46Z | - |
| dc.date.issued | 2015-02 | - |
| dc.date.issued | 2017-05-02T20:15:44Z | - |
| dc.identifier | Alberton, Kese Pontes Freitas; Alberton, André Luís; Di Maggio, Jimena Andrea; Estrada, Vanina Gisela; Díaz, María Soledad; et al.; Simultaneous Parameters Identifiability and Estimation of an E. coli Metabolic Network Model; Hindawi Publishing Corporation; Biomed Research International; 2015; 2-2015; 1-21; 454765 | - |
| dc.identifier | 2314-6133 | - |
| dc.identifier | http://hdl.handle.net/11336/24451 | - |
| dc.identifier | 2314-6141 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297045 | - |
| dc.description | This work proposes a procedure for simultaneous parameters identifiability and estimation in metabolic networks in order to overcome difficulties associated with lack of experimental data and large number of parameters, a common scenario in themodeling of such systems. As case study, the complex real problem of parameters identifiability of the Escherichia coli K-12 W3110 dynamic model was investigated, composed by 18 differential ordinary equations and 35 kinetic rates, containing 125 parameters. With the procedure, model fit was improved formost of the measured metabolites, achieving 58 parameters estimated, including 5 unknown initial conditions.The results indicate that simultaneous parameters identifiability and estimation approach in metabolic networks is appealing, since model fit to the most of measured metabolites was possible even when important measures of intracellular metabolites and good initial estimates of parameters are not available. | - |
| dc.description | Fil: Alberton, Kese Pontes Freitas. Universidade Federal do Rio de Janeiro; Brasil | - |
| dc.description | Fil: Alberton, André Luís. Universidade Do Estado de Rio Do Janeiro; Brasil | - |
| dc.description | Fil: Di Maggio, Jimena Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina | - |
| dc.description | Fil: Estrada, Vanina Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina | - |
| dc.description | Fil: Díaz, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina | - |
| dc.description | Fil: Resende Secchi, Argimiro. Universidade Federal do Rio de Janeiro; Brasil | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Hindawi Publishing Corporation | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2015/454765 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2015/454765/ | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/24451 | - |
| dc.subject | PARAMETERS IDENTIFIABILITY | - |
| dc.subject | COMPLEX DYNAMIC MODELS | - |
| dc.subject | SCARCE EXPERIMENTAL DATA | - |
| dc.subject | METABOLIC NETWORKS | - |
| dc.subject | ESCHERICHIA COLI | - |
| dc.subject | Otras Ingeniería Química | - |
| dc.subject | Ingeniería Química | - |
| dc.subject | INGENIERÍAS Y TECNOLOGÍAS | - |
| dc.title | Simultaneous Parameters Identifiability and Estimation of an E. coli Metabolic Network Model | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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