Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Angerami, Matias | - |
| dc.creator | Suárez, Guadalupe Verónica | - |
| dc.creator | Vecchione, María Belén | - |
| dc.creator | Laufer, Natalia Lorna | - |
| dc.creator | Ameri, Diego | - |
| dc.creator | Ben, Graciela | - |
| dc.creator | Perez, Hector | - |
| dc.creator | Sued, Omar Gustavo | - |
| dc.creator | Salomon, Horacio Eduardo | - |
| dc.creator | Quiroga, María Florencia | - |
| dc.date | 2018-06-06T19:18:48Z | - |
| dc.date | 2018-06-06T19:18:48Z | - |
| dc.date | 2017-05 | - |
| dc.date | 2018-06-06T13:41:10Z | - |
| dc.date.accessioned | 2019-04-29T15:31:47Z | - |
| dc.date.available | 2019-04-29T15:31:47Z | - |
| dc.date.issued | 2017-05 | - |
| dc.identifier | Angerami, Matias; Suárez, Guadalupe Verónica; Vecchione, María Belén; Laufer, Natalia Lorna; Ameri, Diego; et al.; Expansion of CD25-Negative Forkhead Box P3-Positive T Cells during HIV and Mycobacterium tuberculosis Infection; Frontiers Research Foundation; Frontiers in Immunology; 8; 5-2017; 1-12; 528 | - |
| dc.identifier | 1664-3224 | - |
| dc.identifier | http://hdl.handle.net/11336/47551 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/295857 | - |
| dc.description | Tuberculosis (TB) and HIV alter the immune system, and coinfected (HIV-TB) individuals usually present deregulations of T-lymphocytic immune response. We previously observed an increased frequency of “unconventional” CD4+CD25−FoxP3+ Treg (uTreg) population during HIV-TB disease. Therefore, we aimed to explore the phenotype and function of uTreg and conventional CD4+CD25+FoxP3+ Treg subsets (cTreg) in this context. We evaluated the expression of CD39, programmed cell death protein 1 (PD1), glucocorticoid-induced tumor necrosis factor receptor (GITR), and the effector/memory distribution by flow cytometry in cTreg and uTreg. Also, IL-10, TGF-β, IFN-γ production, and the suppressor capacity of uTregs were analyzed in cocultures with effector lymphocytes and compared with the effect of regulatory T cells (Tregs). We found diminished expression of CD39 and higher levels of PD1 on uTreg compared to cTreg in both HIV-TB and healthy donors (HD). In addition, uTreg and cTreg showed differences in maturation status in both HIV-TB and HD groups, due to the expansion of effector memory uTregs. Interestingly, both HIV-TB and HD showed a pronounced production of IFN-γ in uTreg population, though no significant differences were observed for IL-10 and TGF-β production between uTreg and cTreg. Moreover, IFN-γ+ cells were restricted to the CD39− uTreg population. Finally, when the suppressor capacity was evaluated, both uTreg and cTreg inhibited polyclonal T cell-proliferation and IFN-γ production in a similar extent. These findings suggest that uTregs, which are expanded during HIV-TB coinfection, exert regulatory functions in a similar way to cTregs despite an altered surface expression of Treg characteristic markers and differences in cytokine production. | - |
| dc.description | Fil: Angerami, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina | - |
| dc.description | Fil: Suárez, Guadalupe Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina | - |
| dc.description | Fil: Vecchione, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina | - |
| dc.description | Fil: Laufer, Natalia Lorna. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina | - |
| dc.description | Fil: Ameri, Diego. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; Argentina | - |
| dc.description | Fil: Ben, Graciela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; Argentina | - |
| dc.description | Fil: Perez, Hector. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; Argentina | - |
| dc.description | Fil: Sued, Omar Gustavo. Fundación Huésped; Argentina | - |
| dc.description | Fil: Salomon, Horacio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina | - |
| dc.description | Fil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Frontiers Research Foundation | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fimmu.2017.00528/full | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://doi.org/10.3389/fimmu.2017.00528 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | HUMAN | - |
| dc.subject | INFECTIOUS IMMUNITY BACTERIA | - |
| dc.subject | REGULATORY MECHANISMS | - |
| dc.subject | CYTOKINES | - |
| dc.subject | EFFECTOR/MEMORY TREG POPULATIONS | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Expansion of CD25-Negative Forkhead Box P3-Positive T Cells during HIV and Mycobacterium tuberculosis Infection | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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