Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Bulffer, Romina Fernanda | - |
| dc.creator | Castro, Jose Alberto | - |
| dc.creator | Fanelli, Silvia Laura | - |
| dc.date | 2017-09-21T21:30:19Z | - |
| dc.date | 2017-09-21T21:30:19Z | - |
| dc.date | 2011-05 | - |
| dc.date | 2017-09-19T14:35:33Z | - |
| dc.date.accessioned | 2019-04-29T15:31:28Z | - |
| dc.date.available | 2019-04-29T15:31:28Z | - |
| dc.date.issued | 2011-05 | - |
| dc.identifier | Bulffer, Romina Fernanda; Castro, Jose Alberto; Fanelli, Silvia Laura; Benznidazole levels in blood vary with age in rats; Fundacao Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 106; 3; 5-2011; 374-377 | - |
| dc.identifier | 0074-0276 | - |
| dc.identifier | http://hdl.handle.net/11336/24892 | - |
| dc.identifier | 1678-8060 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/295736 | - |
| dc.description | Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the present study, we determined Bz blood levels in rats of different ages that received Bz intragastrically (100 mg/kg). We developed and validated a high-pressure liquid chromatography with UV detector method for determination of Bz levels in whole blood. Bz levels were significantly higher and persisted for longer periods of time in the blood of young rats when compared to that of adult animals. | - |
| dc.description | Fil: Bulffer, Romina Fernanda. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas para la Defensa; Argentina | - |
| dc.description | Fil: Castro, Jose Alberto. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas para la Defensa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Fanelli, Silvia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Limnología "Dr. Raúl A. Ringuelet". Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Instituto de Limnología; Argentina. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas para la Defensa; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Fundacao Oswaldo Cruz | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/nxtdz4 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1590/S0074-02762011000300021 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Benznidazole | - |
| dc.subject | rat blood | - |
| dc.subject | Chagas Disease | - |
| dc.subject | HPLC | - |
| dc.title | Benznidazole levels in blood vary with age in rats | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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