1. RODNA
  2. CONICET
  3. CONICET
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.creatorNuñez, Julio-
dc.creatorRabinovich, Gabriel Adrian-
dc.creatorSandino, Justo-
dc.creatorMainar, Luis-
dc.creatorPalau, Patricia-
dc.creatorSantas, Enrique-
dc.creatorVillanueva, María Pilar-
dc.creatorNuñez, Eduardo-
dc.creatorBodi, Vicent-
dc.creatorChorro, Francisco-
dc.creatorMiñana, Gema-
dc.creatorSanchis, Juan-
dc.date2015-12-22T17:17:17Z-
dc.date2015-12-22T17:17:17Z-
dc.date2015-04-13-
dc.date2016-03-30 10:35:44.97925-03-
dc.date.accessioned2019-04-29T15:27:53Z-
dc.date.available2019-04-29T15:27:53Z-
dc.date.issued2015-12-22T17:17:17Z-
dc.date.issued2015-12-22T17:17:17Z-
dc.date.issued2015-04-13-
dc.date.issued2016-03-30 10:35:44.97925-03-
dc.identifierNuñez, Julio; Rabinovich, Gabriel Adrian; Sandino, Justo; Mainar, Luis; Palau, Patricia; et al.; Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure; Public Library Of Science; Plos One; 10; 4; 13-4-2015; 1-14-
dc.identifier1932-6203-
dc.identifierhttp://hdl.handle.net/11336/3155-
dc.identifier1932-6203-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294631-
dc.descriptionAIM:Galectin-3 (Gal-3) and carbohydrate antigen 125 (CA125) have emerged as robust prognostic biomarkers in heart failure. Experimental data have also suggested a potential molecular interaction between CA125 and Gal-3; however, the biological and clinical relevance of this interaction is still uncertain. We sought to evaluate, in patients admitted for acute heart failure, the association between plasma Gal-3 with all-cause mortality and the risk for rehospitalizations among high and low levels of CA125. METHODS AND RESULTS: We included 264 consecutive patients admitted for acute heart failure to the Cardiology Department in a third-level center. Both biomarkers were measured on admission. Negative binomial and Cox regression models were used to evaluate the prognostic effect of the interaction between Gal-3 and CA125 (dichotomized by its median) with hospital readmission and all-cause mortality, respectively. During a median follow-up of 2 years (IQR = 1-2.8), 108 (40.9%) patients deaths and 365 rehospitalizations in 171 (69.5%) patients were registered. In a multivariable setting, the effect of Gal-3 on mortality and rehospitalization was differentially mediated by CA125 (p = 0.007 and p<0.001, respectively). Indeed, in patients with CA125 above median (>67 U/ml), values across the continuum of Gal-3 showed a positive and almost linear relationship with either the risk of death or rehospitalization. Conversely, when CA125 was below median (≤67 U/ml), Gal-3 lacked any prognostic effect on both endpoints. CONCLUSION: In patients with acute heart failure, Gal-3 was strongly associated with higher risk of long-term mortality and repeated rehospitalizations, but only in those patients exhibiting higher values of CA125.-
dc.descriptionFil: Nuñez, Julio. Universidad de Valencia; España-
dc.descriptionFil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires; ; Argentina-
dc.descriptionFil: Sandino, Justo. Universidad de Valencia; España-
dc.descriptionFil: Mainar, Luis. Universidad de Valencia; España-
dc.descriptionFil: Palau, Patricia. Hospital de La Plana; España-
dc.descriptionFil: Santas, Enrique. Universidad de Valencia; España-
dc.descriptionFil: Villanueva, María Pilar.-
dc.descriptionFil: Nuñez, Eduardo. Universidad de Valencia; España-
dc.descriptionFil: Bodi, Vicent. Universidad de Valencia; España-
dc.descriptionFil: Chorro, Francisco. Universidad de Valencia; España-
dc.descriptionFil: Miñana, Gema. Hospital de Manises; España-
dc.descriptionFil: Sanchis, Juan. Universidad de Valencia; España-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherPublic Library Of Science-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395409/pdf/pone.0122360.pdf-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://doi.org/ doi:10.1371/journal.pone.0122360-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightsAtribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectGALECTIN-3-
dc.subjectANTIGEN CARBOHYDRATE 125-
dc.subjectACUTE HEART FAILURE-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titlePrognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
Aparece en las colecciones: CONICET

Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro sencillo del ítem