Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Goulding, Martyn | - |
| dc.creator | Lanuza, Guillermo Marcos | - |
| dc.creator | Frank, Eric | - |
| dc.creator | Alvarez, Francisco J | - |
| dc.creator | Velasquez, Tomoko | - |
| dc.creator | Zhang, Ying | - |
| dc.creator | Siembad, Valerie C | - |
| dc.creator | Wan, Zhi | - |
| dc.creator | Britz, Olivier | - |
| dc.creator | Zhang, Jingming | - |
| dc.date | 2016-11-24T17:27:25Z | - |
| dc.date | 2016-11-24T17:27:25Z | - |
| dc.date | 2014-04 | - |
| dc.date | 2016-11-18T15:20:15Z | - |
| dc.date.accessioned | 2019-04-29T15:27:16Z | - |
| dc.date.available | 2019-04-29T15:27:16Z | - |
| dc.date.issued | 2016-11-24T17:27:25Z | - |
| dc.date.issued | 2016-11-24T17:27:25Z | - |
| dc.date.issued | 2014-04 | - |
| dc.date.issued | 2016-11-18T15:20:15Z | - |
| dc.identifier | Goulding, Martyn; Lanuza, Guillermo Marcos; Frank, Eric; Alvarez, Francisco J; Velasquez, Tomoko; et al.; V1 and V2b Interneurons Secure the Alternating Flexor-Extensor Motor Activity Mice Require for Limbed Locomotion; Cell Press; Neuron; 82; 1; 4-2014; 138-150 | - |
| dc.identifier | 0896-6273 | - |
| dc.identifier | http://hdl.handle.net/11336/8355 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294442 | - |
| dc.description | Reciprocal activation of flexor and extensor muscles constitutes the fundamental mechanism that tetrapod vertebrates use for locomotion and limbdriven reflex behaviors. This aspect of motor coordination is controlled by inhibitory neurons in the spinal cord; however, the identity of the spinal interneurons that serve this function is not known. Here, we show that the production of an alternating flexor-extensor motor rhythm depends on the composite activities of two classes of ventrally located inhibitory neurons, V1 and V2b interneurons (INs). Abrogating V1 and V2b IN-derived neurotransmission in the isolated spinal cord results in a synchronous pattern of L2 flexor-related and L5 extensor-related locomotor activity. Mice lacking V1 and V2b inhibition are unable to articulate their limb joints and displaymarked deficits in limb-driven reflex movements. Taken together, these findings identify V1- and V2b-derived neurons as the core interneuronal components of the limb central pattern generator (CPG) that coordinate flexor-extensor motor activity. | - |
| dc.description | Fil: Goulding, Martyn. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos | - |
| dc.description | Fil: Lanuza, Guillermo Marcos. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos | - |
| dc.description | Fil: Frank, Eric. Tufts University School of Medicine. Department of Molecular Physiology and Pharmacology; Estados Unidos | - |
| dc.description | Fil: Alvarez, Francisco J. Wright State University. Department of Neurosciences, Cell Biology, and Physiology; Estados Unidos. Emory University. Department of Physiology; Estados Unidos | - |
| dc.description | Fil: Velasquez, Tomoko. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos | - |
| dc.description | Fil: Zhang, Ying. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos. Dalhousie University. Department of Anatomy and Neurobiology; Canadá | - |
| dc.description | Fil: Siembad, Valerie C. Wright State University. Department of Neurosciences, Cell Biology, and Physiology; Estados Unidos | - |
| dc.description | Fil: Wan, Zhi. Tufts University School of Medicine. Department of Molecular Physiology and Pharmacology; Estados Unidos | - |
| dc.description | Fil: Britz, Olivier. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos | - |
| dc.description | Fil: Zhang, Jingming. Salk Institute for Biological Studies. Molecular Neurobiology Laboratory; Estados Unidos | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Cell Press | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://www.sciencedirect.com/science/article/pii/S0896627314001111 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuron.2014.02.013 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096991/ | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | motor system | - |
| dc.subject | spinal reflex | - |
| dc.subject | interneuron | - |
| dc.subject | CPG | - |
| dc.subject | Neurociencias | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | V1 and V2b Interneurons Secure the Alternating Flexor-Extensor Motor Activity Mice Require for Limbed Locomotion | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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