Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Samelo, Jaime | - |
| dc.creator | Mora, Maria Julia | - |
| dc.creator | Granero, Gladys Ester | - |
| dc.creator | Moreno, Maria João | - |
| dc.date | 2018-12-05T12:51:57Z | - |
| dc.date | 2018-12-05T12:51:57Z | - |
| dc.date | 2017-02 | - |
| dc.date | 2018-10-22T19:36:32Z | - |
| dc.date.accessioned | 2019-04-29T15:26:55Z | - |
| dc.date.available | 2019-04-29T15:26:55Z | - |
| dc.date.issued | 2017-02 | - |
| dc.identifier | Samelo, Jaime; Mora, Maria Julia; Granero, Gladys Ester; Moreno, Maria João; Partition of Amphiphilic Molecules to Lipid Bilayers by ITC: LowAffinity Solutes; American Chemical Society; ACS Omega; 2; 10; 2-2017; 6863-6869 | - |
| dc.identifier | 2470-1343 | - |
| dc.identifier | http://hdl.handle.net/11336/65828 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294338 | - |
| dc.description | A protocol is developed to allow the accurate characterization of partition to lipid bilayers for solutes with low affinity, using isothermal titration calorimetry. The methodology proposed is suitable for studies using complex membranes, such as intact biomembranes or whole cells. In the method developed, the association is characterized at increasing solute concentrations. This allows the characterization of solute partition into unperturbed membranes, as well as effects induced by high solute concentrations. Most druglike molecules are expected to interact with lowto-moderate affinity with relevant cell membranes. This is due to both the need for a relatively high aqueous solubility of the drug and the poor binding properties of the cell membranes. The methodology is applied to characterize the interaction of antibiotic Rifampicin with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and with lipid bilayers representative of bacterial membranes. | - |
| dc.description | Fil: Samelo, Jaime. CQC-Biological Chemistry Group; Portugal | - |
| dc.description | Fil: Mora, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina | - |
| dc.description | Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina | - |
| dc.description | Fil: Moreno, Maria João. CQC-Biological Chemistry Group; Portugal | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Chemical Society | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/pdf/10.1021/acsomega.7b01145 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1021/acsomega.7b01145 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | PARTITION OF AMPHIPHILIC MOLECULES | - |
| dc.subject | LIPID BILAYERS | - |
| dc.subject | ISOTHERMAL TITRATION CALORIMETRY | - |
| dc.subject | RIFAMPICIN | - |
| dc.subject | Nano-materiales | - |
| dc.subject | Nanotecnología | - |
| dc.subject | INGENIERÍAS Y TECNOLOGÍAS | - |
| dc.title | Partition of Amphiphilic Molecules to Lipid Bilayers by ITC: LowAffinity Solutes | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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