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Campo DC Valor Lengua/Idioma
dc.provenanceCONICET-
dc.creatorVelez Pardo, Carlos-
dc.creatorJimenez Del Rio, Marlene-
dc.creatorLores Arnaiz, Silvia-
dc.creatorBustamante, Juanita-
dc.date2019-01-07T19:28:58Z-
dc.date2019-01-07T19:28:58Z-
dc.date2010-09-
dc.date2019-01-07T13:32:52Z-
dc.date.accessioned2019-04-29T15:26:10Z-
dc.date.available2019-04-29T15:26:10Z-
dc.date.issued2019-01-07T19:28:58Z-
dc.date.issued2019-01-07T19:28:58Z-
dc.date.issued2010-09-
dc.date.issued2019-01-07T13:32:52Z-
dc.identifierVelez Pardo, Carlos; Jimenez Del Rio, Marlene; Lores Arnaiz, Silvia; Bustamante, Juanita; Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure; Springer/Plenum Publishers; Neurochemical Research; 35; 9; 9-2010; 1323-1332-
dc.identifier0364-3190-
dc.identifierhttp://hdl.handle.net/11336/67604-
dc.identifier1573-6903-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294148-
dc.descriptionThe effects of cannabinoids in mitochondria after acute oxidative stress insult are not fully established. We investigated the ability of CP55,940 and JWH-015 to scavenge reactive oxygen species and their effect on mitochondria permeability transition (MPT) in either A mitochondria-free superoxide anion generation system, intact rat brain mitochondria or in sub-mitochondrial particles (SMP) treated with paraquat (PQ). Oxygen consumption, mitochondrial membrane potential (δ φm) and MPT were determined as parameters of mitochondrial function. It is found that both cannabinoids effectively attenuate mitochondrial damage against PQ-induced oxi-dative stress by scavenging anion superoxide radical (O2-) and hydrogen peroxide (H2O2), maintaining φm and by avoiding Ca2+-induced mitochondrial swelling. Understanding the mechanistic action of cannabinoids on mitochondria might provide new insights into more effective therapeutic approaches for oxidative stress related disorders.-
dc.descriptionFil: Velez Pardo, Carlos. Universidad de Antioquia; Colombia-
dc.descriptionFil: Jimenez Del Rio, Marlene. Universidad de Antioquia; Colombia-
dc.descriptionFil: Lores Arnaiz, Silvia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Bustamante, Juanita. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherSpringer/Plenum Publishers-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11064-010-0188-1-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11064-010-0188-1-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/67604-
dc.subjectCANNABINOIDS-
dc.subjectCP55,940-
dc.subjectJWH-015 MITOCHONDRIA-
dc.subjectOXIDATIVE STRESS-
dc.subjectPARAQUAT-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleProtective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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